Polymorphism of beta2-adrenoceptor and Regular Use of Formoterol in Asthma

NCT ID: NCT01786616

Last Updated: 2013-02-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2005-01-31

Brief Summary

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Polymorphism at codon 16 of the beta2-adrenoceptor (beta2-AR) affects the responsiveness to salmeterol in asthmatics. Data concerning formoterol are more controversial in literature. The aim of this study was to verify whether homozygote for arginine-16 (ArgArg16) and homozygote for glycine-16 (GlyGly16) genotypes differently influence the long-term responsiveness to formoterol.

Detailed Description

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Conditions

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Asthma

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Formoterol

12 mcg BID for four weeks

Formoterol

Intervention Type DRUG

Interventions

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Formoterol

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Mild to moderate asthma
* Stable clinical conditions

Exclusion Criteria

* Smokers
* Current therapy with oral steroids
* Exacerbations within the past 3 months
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Catholic University, Italy

OTHER

Sponsor Role lead

Responsible Party

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Leonello Fuso

Researcher

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Catholic University, Pneumology Unit

Rome, , Italy

Site Status

Countries

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Italy

Other Identifiers

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UCSC-AG-16

Identifier Type: -

Identifier Source: org_study_id

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