Therapeutic Drug Monitoring and Continuous Infusion of Beta-lactam Antibiotics in Patients With Bacteraemia
NCT ID: NCT03108690
Last Updated: 2023-03-29
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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WITHDRAWN
PHASE4
INTERVENTIONAL
2017-10-01
2023-03-09
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
FACTORIAL
TREATMENT
SINGLE
Study Groups
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TDM and CI.
Continuous infusion of beta-lactam antibiotics. Therapeutic drug monitoring of beta-lactam antibiotics.
Continuous infusion of beta-lactam antibiotics .
Beta-lactam antibiotic will be administered as continous infusion.
Therapeutic drug monitoring of beta-lactam antibiotics.
Dosage of beta-lactam antibiotics will be adjusted according to serum concentration.
Control
Beta-lactam antibiotics given as intermittent infusion. Samples of serum concentration of beta-lactam will be collected for comparison, but blinded during the study.
No interventions assigned to this group
Interventions
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Continuous infusion of beta-lactam antibiotics .
Beta-lactam antibiotic will be administered as continous infusion.
Therapeutic drug monitoring of beta-lactam antibiotics.
Dosage of beta-lactam antibiotics will be adjusted according to serum concentration.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Undergo treatment with either intravenous penicillin, ampicillin, piperacillin/tazobactam, dicloxacillin, cefuroxime or meropenem.
* Hospitalised at Hvidovre University Hospital.
* Age ≥ 18.
* Able to understand and give informed consent.
* Included in the study within 24 hours after the final positive blood culture answer.
Exclusion Criteria
* The patient dies before the intervention.
18 Years
ALL
No
Sponsors
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Sara Thønnings
OTHER
Responsible Party
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Sara Thønnings
MD
Principal Investigators
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Sara Thønnings, MD
Role: PRINCIPAL_INVESTIGATOR
Hvidovre University Hospital
Other Identifiers
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2015-768
Identifier Type: -
Identifier Source: org_study_id
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