Understanding How Anaesthesia Affects ECT Outcomes

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

54 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-03-15

Study Completion Date

2019-03-15

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study will examine how anaesthetic technique affects ECT outcomes. Specifically, the investigators will examine how: 1) the time interval between anaesthetic and ECT stimulus, and 2) the ventilation rate before ECT stimulus, impacts on the quality of the EEG (this is a recording of brain activity during ECT and is used to judge the quality of a seizure and to guide individual patient dosing).

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Ketamine as an Anaesthetic Agent in Electroconvulsive Therapy (ECT)

NCT00680433

Major Depressive Episode

COMPLETED PHASE4

Hyperventilation Combined With Etomidate or Ketamine Anesthesia in ECT Treatment of Major Depression

NCT02924090

Depression

UNKNOWN PHASE4

Clinical Outcomes With Electroconvulsive Therapy: Insights From Computational Modelling

NCT03297411

Depression

UNKNOWN PHASE2

EEG Characteristics in ECT

NCT04022226

Electroconvulsive Therapy Direct Current Electroencephalogram Ketamine +1 more

COMPLETED EARLY_PHASE1

Measurement of Anaesthesia-depth Trough Narcotrend TM in Patients Undergoing Electro-Convulsion-Therapy (ECT)- Influence of Anasthesia Depth on Quality of Convulsion

NCT03897985

Anesthesia

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

This study aims to examine how the time interval between administration of anaesthetic agent and ECT stimulus delivery impacts upon measures of EEG quality (seizure quality).

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Depression

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Each participant will receive all four treatment conditions in randomly allocated sequence during their ECT course. That is, participants will receive either short or long anaesthetic-ECT stimulus time interval treatments, and normal or hyperventilation treatments - this results in four possible combinations, which individual participants will cycle through in random order during their ECT course (e.g. short-hyperventilation, long-normal ventilation, short-normal ventilation, long-hyperventilation).

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Both participants and the outcome assessor (analysing EEGs) will be blinded.

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.