Medical and Physiological Benefits of Reduced Sitting

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

64 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-04-25

Study Completion Date

2020-03-04

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The most important objective of this randomized controlled trial in subjects with increased cardiovascular and metabolic risk factors is to investigate whether only reduced daily sitting improves human cardiovascular and metabolic health during a six-month intervention. It is hypothesized and expected that only reduced sitting, without formal physical activity or exercise training, affects favorably cardiovascular and metabolic health.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Effect of Interrupting Sedentary Time With Different Frequencies of Physical Activity on Cardiometabolic Risk Factors

NCT05622006

Sedentary Cardiometabolic Syndrome Physical Activity

COMPLETED NA

Effects of Disrupting Prolonged Sitting With Different Physical Activity Protocols on Metabolic Risk Factors in Sedentary Adults

NCT02215603

Prolonged Sitting Breaking Prolonged Sitting With Physical Activity

UNKNOWN NA

Effects of Interrupting Sedentary Behavior With High - or Low Intensity PA on CVD - and Cardiometabolic Riskfactors, and Cognitive Performance.

NCT05709379

Sedentary Behavior Physical Activity

COMPLETED NA

The Effect of Breaking up Sitting in the Workplace on Cardiometabolic Risk and Worker Productivity

NCT03560544

Sedentary Lifestyle

UNKNOWN NA

SIT LESS 3: The Effect of Low Intensity Physical Activity on Insulin Sensitivity, Mood and Cognitive Performance

NCT02394249

Overweight Obesity

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Metabolic Syndrome Physical Activity Insulin Resistance Cardiovascular Diseases

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

A parallel-group randomised controlled trial

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Outcome Assessors

Due to the nature of the intervention, masking of the participants is not possible. Analyzing of the obtained data will be masked.

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Reduced sitting

Objectively measured daily inactive time will be reduced by one hour compared to the baseline.

Group Type EXPERIMENTAL

Reduced sitting

Intervention Type BEHAVIORAL

Subjects are guided to limit their sitting time during the day for 1 hour/day, by adding light activity with the help of an activity monitor. Subjects are not encouraged to increase their moderate to vigorous physical activity levels.

Control

Subjects will be guided to maintain their normal sedentary behaviour and physical activity habits.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Reduced sitting

Subjects are guided to limit their sitting time during the day for 1 hour/day, by adding light activity with the help of an activity monitor. Subjects are not encouraged to increase their moderate to vigorous physical activity levels.

Intervention Type BEHAVIORAL

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Physically inactive (less than 120 minutes of moderate intensity exercise per week measured by the activity monitor during run-in)
* Sitting time ≥ 10 h /day (measured by the activity monitor during run-in)
* BMI 25-40
* Blood pressure \< 160/100 mmHg
* Fasting plasma glucose \< 7.0 mmol/l
* Fulfills the criteria of the metabolic syndrome according to Alberti et al 2009

Exclusion Criteria

* History of a cardiac event
* Insulin or medically treated diabetes
* Any chronic disease or condition that could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results
* Presence of ferromagnetic objects that would make MR imaging contraindicated
* Abundant use of alcohol
* Use of narcotics
* Smoking of tobacco or consuming snuff tobacco
* Diagnosed depressive or bipolar disorder
* Previous PET imaging or considerable exposure to radiation

Minimum Eligible Age

40 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes