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Hepatopulmonary Syndrome and ...

Hepatopulmonary Syndrome and Postoperative Complications After Liver Transplantation : A Case-control Study

Last Updated: 2017-03-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

142 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-10-01

Study Completion Date

2017-03-31

Brief Summary

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Hepatopulmonary Syndrome is a respiratory complication of liver cirrhosis defined as a triad: hypoxemia (PaO2 \< 80 mmHg in room air), chronic liver disease and intrapulmonary vasodilatations. Its prevalence varies between 4 and 32%. Numerous treatments have been tried but the only efficient therapy to cure the syndrome is liver transplantation. Without transplantation it is associated with a higher mortality which is the reason why hepatopulmonary syndrome patients have a higher priority to transplantation. However it appears in some restricted studies that hepatopulmonary syndrome is associated with more postoperative complications (infections, vascular and biliary complications, prolonged length of mechanical ventilation…).

The investigators hypothesised that hepatopulmonary syndrome patients have more postoperative complications after liver transplantation than non hepatopulmonary syndrome patients matched on age, MELD (Model for End-Stage Liver Disease) score, comorbidities, perioperative transfusion and noradrenaline doses.

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Detailed Description

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Conditions

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Hepatopulmonary Syndrome Liver Cirrhosis

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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hepatic transplant patients with hepatopulmonary syndrome

No interventions assigned to this group

hepatic transplant patients without hepatopulmonary syndrome

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Liver transplanted patients

Exclusion Criteria

* Living donor transplantation
* Bipartition transplantation
* Non-heat-beating donor transplantation
* Minor
* Double or multiple organ transplantation
* Non cirrhotic patients
* Retransplantation

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers