MicroRNAs in Acute Kidney Injury

NCT ID: NCT03089242

Last Updated: 2020-05-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

150 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-09-01

Study Completion Date

2018-12-31

Brief Summary

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Profiling of microRNAs and long noncoding RNAs (lncRNAs) in patients undergoing cardiac surgery. Analysis: Prediction of acute kidney injury by plasma expression profile of microRNAs?

Detailed Description

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In this pilot study we will include 150 patients undergoing cardiac surgery in a German university hospital. We will profile microRNA expression in plasma and urine before and at several timepoints after surgery. We will use a preselected panel of microRNAs and lncRNAs for analysis. Goal is to identify microRNAs/lncRNAs that are able to predict the occurence of AKI in these patients.

Conditions

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Kidney Injury in Cardiac Surgery - Expression of microRNAs

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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observation of microRNA expression

no intervention

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* cardiac surgery

Exclusion Criteria

* preexisting chronic kidney injury
* inclusion in another study
* pregnancy
* Kidney transplantation in history
* GFR \< 30 ml/min (glomerular filtration rate)
* ECLS therapy (extracorporal life support)
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Heinrich-Heine University, Duesseldorf

OTHER

Sponsor Role lead

Responsible Party

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Klinik für Anästhesiologie

PD Dr. Timo Brandenburger

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Timo Brandenburger, M.D.

Role: PRINCIPAL_INVESTIGATOR

Klinik für Anästhesiologie, Heinrich-Heine-Universität Düsseldorf

Locations

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Klinik für Anästhesiologie

Düsseldorf, , Germany

Site Status

Countries

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Germany

Other Identifiers

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2017024132

Identifier Type: -

Identifier Source: org_study_id

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