Circuit-Based Deep Brain Stimulation for Parkinson's Disease; Udall Project 1 Aim 2 and 3

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

15 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-06-19

Study Completion Date

2023-01-29

Brief Summary

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This study will test the hypothesis that deep brain stimulation (DBS) targeting specific changes in oscillatory activity at the site of stimulation will prove superior to continuous isochronal DBS thus providing the rationale for development and optimization of closed loop paradigms and determine whether the optimal closed-loop biomarker varies across subcortical targets, is task dependent, or serves to re-establish a default network that removes an underlying disruptive physiological state leading to greater improvement in motor signs and task performance.

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Detailed Description

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Conditions

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Parkinson Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Stimulation

Traditional deep brain stimulation

Stimulation

Intervention Type DEVICE

Traditional deep brain stimulation

Interventions

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Stimulation

Traditional deep brain stimulation

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of idiopathic PD
* DBS surgery or IPG battery replacement at UMN is planned as part of routine clinical care.

Exclusion Criteria

* Other significant neurological disorder
* History of dementia
* Prior history of stereotactic neurosurgery
* Patients with post-operative complications or adverse effects (e.g. ON stimulation dystonias) that affect patient safety or confound the experiment will be excluded from further study
* Pregnant women

Minimum Eligible Age

22 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No