Efficacy and Safety of APD334 in Patients With Pyoderma Gangrenosum

NCT ID: NCT03072953

Last Updated: 2021-06-11

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: PHASE2
• Total Enrollment: 2 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2017-06-07
• Study Completion Date: 2018-05-22

Brief Summary

The purpose of this Phase 2a, open label, proof-of-concept clinical study is to assess the efficacy and safety of etrasimod (APD334) in patients with Pyoderma Gangrenosum.

Conditions

Pyoderma Gangrenosum

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

APD334

APD334 active treatment for 12 weeks.

Group Type: OTHER

APD334

Intervention Type: DRUG

APD334 active treatment

Interventions

APD334

APD334 active treatment

Intervention Type: DRUG

Other Intervention Names

Etrasimod

Eligibility Criteria

Inclusion Criteria

1. Male or female (18-80 years).

2. Able to provide a signed informed consent prior to any study related procedure being conducted.

3. Diagnosis of PG with active, non-healing ulcer.

4. Considered to be in stable health in the opinion of the investigator as determined by:

1. A screening physical examination with no clinically significant abnormalities unrelated to PG.

2. Vital signs at screening: pulse rate ≥ 55 bpm, systolic blood pressure ≥ 90 mmHg, and diastolic blood pressure ≥ 55 mmHg.

3. Liver function tests (alanine aminotransferase/aspartate aminotransferase, bilirubin and alkaline phosphatase) < 2x the upper limit of normal.

4. All other pre-study clinical laboratory findings within normal range, or if outside of the normal range are not deemed clinically significant in the opinion of the investigator with exemption to leucopenia and lymphopenia - please refer to exclusion criterion 24.

5. No clinical abnormalities noted in the12-lead electrocardiogram in the opinion of the investigator (Refer also to exclusion criterion 13).

6. No evidence of macular edema in an ophthalmology evaluation (performed by an ophthalmologist), supported with optical coherence tomography, where available (dependent on site capability) at screening.

5. Eligible male and female participants must agree not to participate in a conception process (i.e. active attempt to let female partner to become pregnant or to impregnate, sperm donation, oocyte donation, in vitro fertilization) for at least 30 days after the last dose of study drug.

Non-sterile participants who are sexually active must take adequate contraception measures.

Exclusion Criteria

1. Clinically significant infection as judged by the investigator with an end date less than 6-weeks prior to treatment start (Day 1). In case of infection requiring hospitalization or intravenous antimicrobial therapy, or opportunistic infection, this infection must have ended at least 8 weeks prior to Day 1.

2. Infection with hepatitis C virus anytime in the past; confirmed active infection with hepatitis B virus at screening.

3. History of severe renal or severe hepatic impairment.

4. Current active or latent tuberculosis (TB).

5. A positive diagnostic TB test at screening.

6. Exposure to B-cell or T-cell targeted therapies (such as natalizumab, rituximab, abatacept) within 5 half-lives prior to Day 1.

7. Exposure to other immunosuppressive, immunomodulating or antineoplastic agents.

8. Receipt of any investigational agent within 30 days or 5 half lives (whichever is longer), prior to Day 1.

9. Use of moderate to strong inhibitors of CYP2C9.

10. Abnormal forced expiratory volume (FEV1) or forced vital capacity (FVC).

11. Any known history of congenital or acquired immuno-deficiency.

12. Recent history (within 6 months of screening visit) of cardio- or cerebrovascular disease, acute coronary syndrome, myocardial infarction, unstable angina, cerebro-vascular accident, including transient ischemic attack.

13. History or presence of cardiac arrhythmia, conduction system disease, or use of Class Ia or Class III anti arrhythmic agents, or baseline QTc ≥ 500 msec.

14. Congestive heart failure (NYHA III or NYHA IV)

15. Any surgical procedure requiring general anesthesia within 30 days prior to Day 1 or plans to undergo major surgery during the study period.

16. History of retinal macular edema.

17. History of or signs and symptoms of progressive multifocal leukoencephalopathy (PML) as assessed by the PML checklist at screening.

18. History of more than one episode of herpes zoster or any episode of disseminated zoster.

19. Participants without documented positive varicella zoster virus (VZV) IgG antibody status or participants who have not completed VZV vaccination within 6 weeks prior to Day 1.

20. Receipt of live vaccine within 6 weeks prior to Day 1.

21. History of lymphoproliferative disorder, lymphoma, leukemia, myeloproliferative disorder, or multiple myeloma.

22. History of malignancy except for adequately treated basal cell skin cancer and in situ carcinoma of the cervix of the uterus that have been completely excised with documented, clear margins.

23. History of severe allergic or anaphylactic reactions requiring medical attention.

24. Leukopenia or lymphopenia at screening.

25. Current or recent history (within 1 year prior to Day 1) of alcohol dependence or illicit drug use.

26. Active psychiatric problems that, in the investigator's opinion, may interfere with compliance with the study procedures.

27. History of any other clinically significant medical condition that, in the investigator's opinion, would preclude participant from safe participation in the study.

28. Inability to attend all the study visits or comply with study procedures.

29. Prior exposure to etrasimod (APD334) or prior participation in any study of etrasimod (APD334).

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Arena Pharmaceuticals

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Arena CT.gov Administrator

Role: STUDY_DIRECTOR

Arena Pharmaceuticals

Locations

Westmead Hospital

Westmead, New South Wales, Australia

Veracity Clinical Research

Woolloongabba, Queensland, Australia

Eastern Clinical Research Unit

Box Hill, Victoria, Australia

Royal Melbourne Hospital

Parkville, Victoria, Australia

Fremantle Dermatology

Fremantle, Western Australia, Australia

Braemar Day Hospital

Hamilton, , New Zealand

Countries

Australia; New Zealand

Provided Documents

Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

APD334-011

Identifier Type: -

Identifier Source: org_study_id