A Study of TAK-279 in Adult Participants With Generalized Pustular Psoriasis or Erythrodermic Psoriasis

NCT ID: NCT06323356

Last Updated: 2025-11-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

PHASE3

Total Enrollment

18 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-03-19

Study Completion Date

2026-07-22

Brief Summary

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The main aim of this study is to check if TAK-279 improves symptoms of With Generalized Pustular Psoriasis (GPP) or Erythrodermic Psoriasis (EP) and side effect from the study treatment or TAK-279.

All participants will be assigned to study treatments of TAK-279 and will be treated with TAK-279 if the participants meet the study rules.

Participants will be in the study for up to 61 weeks including 52 weeks of study treatment. During the study, participants will visit their study clinic for multiple times.

Detailed Description

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Conditions

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Generalized Pustular Psoriasis Erythrodermic Psoriasis

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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TAK-279 for Generalized Pustular Psoriasis

Participants with generalized pustular psoriasis will receive TAK-279 from Day 1 up to Week 52.

Group Type EXPERIMENTAL

TAK-279

Intervention Type DRUG

Specified drug on specified days.

TAK-279 for Erythrodermic Psoriasis

Participants with erythrodermic psoriasis will receive TAK-279 from Day 1 up to Week 52.

Group Type EXPERIMENTAL

TAK-279

Intervention Type DRUG

Specified drug on specified days.

Interventions

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TAK-279

Specified drug on specified days.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

1. A diagnosis of GPP or EP prior to the screening visit.
2. Candidate for phototherapy or systemic therapy.

Exclusion Criteria

1. Other forms of psoriasis.
2. History of recent infection.
3. Any prior exposure to TAK-279, or participation in any study that included a TYK2 inhibitor.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Takeda

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Study Director

Role: STUDY_DIRECTOR

Takeda

Locations

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Nagoya City University Hospital

Nagoya, Aichi-ken, Japan

Site Status

Fujita Health University Hospital

Toyoake, Aichi-ken, Japan

Site Status

Kimitsu Chuo Hospital

Kisarazu, Chiba, Japan

Site Status

Juntendo University Urayasu Hospital

Urayasu, Chiba, Japan

Site Status

Hospital of the University of Occupational and Environmental Health, Japan

Kitakyushu, Fukuoka, Japan

Site Status

Isesaki Municipal Hospital

Isesaki, Gunma, Japan

Site Status

Kobe University Hospital

Kobe, Hyōgo, Japan

Site Status

Tokai University Hospital

Isehara, Kanagawa, Japan

Site Status

Mie University Hospital

Tsu, Mie-ken, Japan

Site Status

Kansai Medical University Hospital

Hirakata, Osaka, Japan

Site Status

Saitama Medical University Hospital

Iruma, Saitama, Japan

Site Status

St.Luke's International Hospital

Chūō, Tokyo, Japan

Site Status

Teikyo University Hospital

Itabashi-ku, Tokyo, Japan

Site Status

The Jikei University Hospital

Minato-ku, Tokyo, Japan

Site Status

Tokyo Medical University Hospital

Shinjuku-ku, Tokyo, Japan

Site Status

Fukuoka University Hospital

Fukuoka, , Japan

Site Status

University Hospital, Kyoto Prefectural University of Medicine

Kyoto, , Japan

Site Status

Okayama University Hospital

Okayama, , Japan

Site Status

Nippon Life Hospital

Osaka, , Japan

Site Status

Osaka Metropolitan University Hospital

Osaka, , Japan

Site Status

Countries

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Japan

Other Identifiers

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jRCT2031230714

Identifier Type: REGISTRY

Identifier Source: secondary_id

TAK-279-PsO-3005

Identifier Type: -

Identifier Source: org_study_id

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