Aortic Cross Clamping Time, and Postoperative Respiratory Function

NCT ID: NCT03072784

Last Updated: 2017-03-09

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 53 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2015-02-01
• Study Completion Date: 2016-08-25

Brief Summary

Does the duration of cardiopulmonary bypass, and aortic cross clamping affects the post operative pulmonary function.

Detailed Description

Cardiac surgery usually is done under cardiopulmonary bypass. As the blood contacts with the artificial tubing of the circuit, there is release of mediators which affects pulmonary function. Of no doubt that the duration of cardiopulmonary bypass, and cross clamping time, will affect the spell over of such mediators. Follow up of the pulmonary function, and arterial blood gas is mandatory in such group of patients.

Conditions

Bypass Complication; Respiratory Complication

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: OTHER
• Blinding Strategy: DOUBLE

Study Groups

group S

short time \<90 m aortic cross clamping

Group Type: ACTIVE_COMPARATOR

aortic cross clamping

Intervention Type: PROCEDURE

duration of cross clamping, less than 90 minutes, or more than 90 minutes

group L

\> 90 minutes aortic cross clamping

Group Type: ACTIVE_COMPARATOR

aortic cross clamping

Intervention Type: PROCEDURE

duration of cross clamping, less than 90 minutes, or more than 90 minutes

Interventions

aortic cross clamping

duration of cross clamping, less than 90 minutes, or more than 90 minutes

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

• adult patients
• elective open heart surgery

Exclusion Criteria

• Patients with myocardial ischemia or previous infarction
• low ejection fraction <30%
• history of AF
• implanted pacemaker
• uncontrolled hypertension
• renal impairment (creatinine >1.8 mg/dl)
• hepatic dysfunction
• insulin dependent diabetes
• chronic pulmonary disease

• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

Emad Zarief , MD

Lecturer of Anesthesia and critical care Medicine

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Emad Z kamel Said, MD

Role: PRINCIPAL_INVESTIGATOR

Assiut University

Locations

Emad Zarief Kamel Said

Asyut, Asyut Governorate, Egypt

Countries

Egypt

Other Identifiers

IRB00009915

Identifier Type: -

Identifier Source: org_study_id