Helicobacter Pylori Sample Collection Protocol Pre Therapy Subjects

NCT ID: NCT03060746

Last Updated: 2021-12-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

277 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-02-14

Study Completion Date

2018-05-03

Brief Summary

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The primary objective is to obtain stool samples from pre-therapy subjects already undergoing evaluation for an H. pylori infection by upper esophagogastroduodenoscopy (EGD) and gastric biopsy.

Detailed Description

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Stools will be collected and tested, at a later date, in a clinical performance study with an investigational H. pylori antigen assay. This study will be coordinated by the Sponsor.

Conditions

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Helicobacter Pylori Infection Gastric Ulcer Nausea Abdominal Pain Weight Loss Stomach Ulcer Loss of Appetite Bloating

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Interventions

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Newly Diagnosed

Gastric biopsy tested by composite reference method (CRM) (histology, urease, culture) and stool sample

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Adult ≥ 22 years, either gender
* Subject is symptomatic showing signs and symptoms of gastritis
* Subject is not under evaluation for post-therapy follow up diagnosis
* Subject is already undergoing upper EGD and obtaining a gastric biopsy as part of routine care for H. pylori diagnosing
* Biopsy is obtained from antrum and/or corpus and is tested by CRM
* At least two of the three CRM tests are performed
* Subject whose EGD with biopsy procedure occurred ≤ 7 days prior to stool collection
* Willing and able to sign the IRB approved Informed Consent form for this project, or able to provide Informed Consent in accordance with 21 CFR 50 Subpart B

* Subject with current severe H. pylori infection
* Subject ingested compounds that may interfere with detection of H. pylori e.g. 4 weeks for all antibiotics, 2 weeks for Bismuth preparations or proton pump inhibitors prior to EGD/collection
* Subject recently tested, less than 3 months and knowledge of H. pylori absence
* Subject tested, less than one year and knowledge of H. pylori presence but NOT undergone prescribed treatment
* Pregnant or lactating
* Inability or unwilling to perform required study procedures
* Subject is unable or unwilling to provide informed consent
Minimum Eligible Age

22 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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ICON Clinical Research

INDUSTRY

Sponsor Role collaborator

DiaSorin Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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One (1) Location in Arizonia

Mesa, Arizona, United States

Site Status

One (1) Location in Mission Hills, California

Mission Hills, California, United States

Site Status

One (1) Location in Oxnard, California

Oxnard, California, United States

Site Status

One (1) Location in Florida

Palm Harbor, Florida, United States

Site Status

One (1) Location in Missouri

St Louis, Missouri, United States

Site Status

One (1) Location in Great Neck, New York

Great Neck, New York, United States

Site Status

One (1) Location in North Carolina

Asheville, North Carolina, United States

Site Status

One (1) Location in Ohio

Mentor, Ohio, United States

Site Status

One (1) Location in Greenville, South Carolina

Greenville, South Carolina, United States

Site Status

One (1) Location in Houston, Texas

Houston, Texas, United States

Site Status

One (1) Location in Virginia

Chesapeake, Virginia, United States

Site Status

One (1) Location in Bologna, Italy

Bologna, , Italy

Site Status

Countries

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United States Italy

Other Identifiers

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PRE-TREAT A001

Identifier Type: -

Identifier Source: org_study_id