Topically Applied IDP-118 Lotion and HP Monad Lotion in Subjects With Moderate to Severe Plaque Psoriasis

NCT ID: NCT03058744

Last Updated: 2017-06-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

94 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-04-30

Study Completion Date

2017-01-31

Brief Summary

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Suppression Potential of Topically Applied IDP-118 Lotion and HP Monad Lotion in Subjects with Moderate to Severe Plaque Psoriasis.

Detailed Description

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A Phase 1b Open-Label, Randomized Study Evaluating the Absorption and Systemic Pharmacokinetics and HPA Axis Suppression Potential of Topically Applied IDP-118 Lotion and HP Monad Lotion in Subjects with Moderate to Severe Plaque Psoriasis.

Conditions

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Psoriasis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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IDP-118 Lotion

8 Weeks

Group Type EXPERIMENTAL

IDP-118 Lotion

Intervention Type DRUG

Lotion

HP Monad Lotion

8 Weeks

Group Type EXPERIMENTAL

HP Monad Lotion

Intervention Type DRUG

Lotion

Ultravate Cream

2 Weeks

Group Type ACTIVE_COMPARATOR

Ultravate Cream

Intervention Type DRUG

Cream

Tazorac Cream

4 Weeks

Group Type ACTIVE_COMPARATOR

Tazorac Cream

Intervention Type DRUG

Cream

Interventions

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IDP-118 Lotion

Lotion

Intervention Type DRUG

HP Monad Lotion

Lotion

Intervention Type DRUG

Ultravate Cream

Cream

Intervention Type DRUG

Tazorac Cream

Cream

Intervention Type DRUG

Other Intervention Names

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Lotion Lotion Ultravate Taz

Eligibility Criteria

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Inclusion Criteria

* Male or Female of any race, at least 18 years old of age (inclusive)
* Freely provides both written and oral informed consent.
* Has a clinical diagnosis of psoriasis at the Baseline visit with an Investigator's Global Assessment Score of 3 or 4. The face, scalp ,axillae, and intertriginous areas are to be excluded in this calculation.
* Has an area of plaque psoriasis for topical treatment that involves a BSA of at least 20%.
* The willing and able to avoid prolonged exposure of the treatment area to ultraviolet radiation (natural and artificial) for the duration of the study.

Exclusion Criteria

* Has spontaneously improving or rapidly deteriorating plaque psoriasis or postural psoriasis, as determined by the investigator.
* Presents with psoriasis that was treated with prescription medication and failed to respond to presents).
* Has a history of adrenal disease.
* Presents with any other concurrent skin conditions that could interfere with the evaluation of the treatment areas, as determined by the investigator.
* Is pregnant, nursing, or planning pregnancy during the study period.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Bausch Health Americas, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Lindsey Mathew

Role: STUDY_DIRECTOR

Valeant Pharmaceuticals

Locations

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Valeant Site 12

Anaheim, California, United States

Site Status

Valeant Site 05

Encino, California, United States

Site Status

Valeant Site 01

San Diego, California, United States

Site Status

Valeant Site 07

Santa Rosa, California, United States

Site Status

Valeant Site 10

Orange Park, Florida, United States

Site Status

Valeant Site 09

Sanford, Florida, United States

Site Status

Valeant Site 08

Atlanta, Georgia, United States

Site Status

Valeant Site 04

Plainfield, Indiana, United States

Site Status

Valeant Site 06

New York, New York, United States

Site Status

Valeant Site 11

Philadelphia, Pennsylvania, United States

Site Status

Valeant Site 03

Austin, Texas, United States

Site Status

Valeant Site 02

Katy, Texas, United States

Site Status

Countries

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United States

Other Identifiers

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V01-118A-501

Identifier Type: -

Identifier Source: org_study_id

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