Safety and Efficacy of IDP-122 Lotion When Applied Topically to Subjects With Moderate to Severe Plaque Psoriasis

NCT ID: NCT02785185

Last Updated: 2020-08-27

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

150 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-06-30

Study Completion Date

2017-01-31

Brief Summary

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A Phase 2, Multi-Center, Double-Blind, Randomized, Vehicle-Controlled Study.

Detailed Description

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A Phase 2, Multi-Center, Double-Blind, Randomized, Vehicle-Controlled Study to Compare the Safety and Efficacy of IDP-122 Lotion (0.01% halobetasol propionate) to Ultravate® (halobetasol propionate) Cream, 0.05% in the Treatment of Plaque Psoriasis.

Conditions

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Psoriasis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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IDP-122 Lotion

Lotion

Group Type EXPERIMENTAL

IDP-122 Lotion

Intervention Type DRUG

Lotion

Ultravate Cream

Cream

Group Type ACTIVE_COMPARATOR

Ultravate Cream

Intervention Type DRUG

Cream

IDP-122 Vehicle Lotion

Lotion

Group Type ACTIVE_COMPARATOR

IDP-122 Vehicle Lotion

Intervention Type DRUG

Vehicle

IDP-122 Vehicle Cream

Cream

Group Type ACTIVE_COMPARATOR

IDP-122 Vehicle Cream

Intervention Type DRUG

Vehicle

Interventions

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IDP-122 Vehicle Lotion

Vehicle

Intervention Type DRUG

IDP-122 Vehicle Cream

Vehicle

Intervention Type DRUG

IDP-122 Lotion

Lotion

Intervention Type DRUG

Ultravate Cream

Cream

Intervention Type DRUG

Other Intervention Names

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Lotion Cream Lotion Ultravate

Eligibility Criteria

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Inclusion Criteria

* Male or female, of any race, at least 18 years of age (inclusive).
* Freely provides both verbal and written informed consent.
* Is willing and able to avoid prolonged exposure of the treatment area to ultraviolet radiation (natural and artificial) for the duration of the study.
* Subject is willing to comply with study instructions and return to the clinic for required visits.

Exclusion Criteria

* Has spontaneously improving or rapidly deteriorating plaque psoriasis or pustular psoriasis, as determined by the investigator.
* Presents with psoriasis that was treated with prescription medication and failed to respond to treatment, even partially or temporarily, as determined by the investigator.
* Presents with any concurrent skin condition that could interfere with the evaluation of the treatment areas, as determined by the investigator.
* Is pregnant, nursing an infant, or planning a pregnancy during the study period.
* Has received treatment with any investigational drug or device within 60 days or 5 drug half-lives (whichever is longer) prior to the Baseline visit, or is concurrently participating in another clinical study with an investigational drug or device.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Bausch Health Americas, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Binu J Alexander, MD

Role: STUDY_DIRECTOR

Valeant Pharmaceuticals

Locations

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Valeant Site 05

Rogers, Arkansas, United States

Site Status

Valeant Site 10

Beverly Hills, California, United States

Site Status

Valeant Site 09

Carlsbad, California, United States

Site Status

Valeant Site 13

Los Angeles, California, United States

Site Status

Valeant Site 12

Santa Monica, California, United States

Site Status

Valeant Site 07

Coral Gables, Florida, United States

Site Status

Valeant Site 11

North Miami Beach, Florida, United States

Site Status

Valeant Site 03

Sanford, Florida, United States

Site Status

Valeant Site 08

Albany, Indiana, United States

Site Status

Valeant Site 04

Louisville, Kentucky, United States

Site Status

Valeant Site 06

Fridley, Minnesota, United States

Site Status

Valeant Site 02

High Point, North Carolina, United States

Site Status

Valeant Site 01

Houston, Texas, United States

Site Status

Countries

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United States

References

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Kerdel FA, Draelos ZD, Tyring SK, Lin T, Pillai R. A phase 2, multicenter, double-blind, randomized, vehicle-controlled clinical study to compare the safety and efficacy of a halobetasol propionate 0.01% lotion and halobetasol propionate 0.05% cream in the treatment of plaque psoriasis. J Dermatolog Treat. 2019 Jun;30(4):333-339. doi: 10.1080/09546634.2018.1523362. Epub 2018 Nov 5.

Reference Type DERIVED
PMID: 30207807 (View on PubMed)

Other Identifiers

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V01-122A-203

Identifier Type: -

Identifier Source: org_study_id

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