Risk Factors for Delirium in Critically Ill Surgical Patients

NCT ID: NCT03050021

Last Updated: 2017-02-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

251 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-04-01

Study Completion Date

2015-08-30

Brief Summary

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Delirium is characterized by changes in mental status, inattension, disorganized thinking, and altered consciousness. Prevalence of delirium in critically ill patients has varied from 20\~80% depending on the severity of illness. Despite its high prevalence, delirium is often under-recognized by clinicians due to the difficulties in diagnosis and no interest. Delirium is associated with increased mechanical ventilation days, hospital length of stay, and mortality. The purpose of this study is to analyze the prevalence of delirium and risk factors for delirium in critically ill surgical patients.

Detailed Description

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The investigators performed a prospective cohort study involving the patients admitted to surgical ICU between april 2013 and august 2013.

The included patients were assessed independently by trained ICU nurses using the confusion Assessment Method for the ICU (CAM-ICU). The patients were recorded general characteristics, disease-related factors, and treatment and environment-related factors. Data were analyzed by SPSS 12.0 software, using t-test, Fisher's exact test and logistic regression.

Conditions

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Delirium Intensive Care Unit Syndrome

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Delirium positive

delirium patients in critically ill surgical patients

No interventions assigned to this group

Delirium negative

non delirium patients in critically ill surgical patients

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

1. Above RASS -3 paitent
2. Verbally or nonverbally communication possible patients

Exclusion Criteria

1. Under age 18
2. Neurological disorder e.g.) Brain injury, dementia and traumatic brain injury
3. Readmitted to ICU
4. History of delirium
5. Transplanted; isolation is required
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Suk-Kyung

OTHER

Sponsor Role lead

Responsible Party

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Suk-Kyung

Associate Professor in General Surgery

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Suk-kyung Hong, Ph.D

Role: PRINCIPAL_INVESTIGATOR

University of Ulsan College of Medicine. Asan Medical Center

Locations

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Asan Medical Center

Seoul, Seoul, South Korea

Site Status

Countries

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South Korea

References

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Dubois MJ, Bergeron N, Dumont M, Dial S, Skrobik Y. Delirium in an intensive care unit: a study of risk factors. Intensive Care Med. 2001 Aug;27(8):1297-304. doi: 10.1007/s001340101017.

Reference Type RESULT
PMID: 11511942 (View on PubMed)

Ely EW, Shintani A, Truman B, Speroff T, Gordon SM, Harrell FE Jr, Inouye SK, Bernard GR, Dittus RS. Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA. 2004 Apr 14;291(14):1753-62. doi: 10.1001/jama.291.14.1753.

Reference Type RESULT
PMID: 15082703 (View on PubMed)

Pisani MA, Araujo KL, Van Ness PH, Zhang Y, Ely EW, Inouye SK. A research algorithm to improve detection of delirium in the intensive care unit. Crit Care. 2006;10(4):R121. doi: 10.1186/cc5027.

Reference Type RESULT
PMID: 16919169 (View on PubMed)

Pisani MA, Kong SY, Kasl SV, Murphy TE, Araujo KL, Van Ness PH. Days of delirium are associated with 1-year mortality in an older intensive care unit population. Am J Respir Crit Care Med. 2009 Dec 1;180(11):1092-7. doi: 10.1164/rccm.200904-0537OC. Epub 2009 Sep 10.

Reference Type RESULT
PMID: 19745202 (View on PubMed)

Hsieh SJ, Ely EW, Gong MN. Can intensive care unit delirium be prevented and reduced? Lessons learned and future directions. Ann Am Thorac Soc. 2013 Dec;10(6):648-56. doi: 10.1513/AnnalsATS.201307-232FR.

Reference Type RESULT
PMID: 24364769 (View on PubMed)

Rapp CG, Mentes JC, Titler MG. Acute confusion/delirium protocol. J Gerontol Nurs. 2001 Apr;27(4):21-33; quiz 62-3. doi: 10.3928/0098-9134-20010401-07.

Reference Type RESULT
PMID: 11915153 (View on PubMed)

Thomason JW, Shintani A, Peterson JF, Pun BT, Jackson JC, Ely EW. Intensive care unit delirium is an independent predictor of longer hospital stay: a prospective analysis of 261 non-ventilated patients. Crit Care. 2005 Aug;9(4):R375-81. doi: 10.1186/cc3729. Epub 2005 Jun 1.

Reference Type RESULT
PMID: 16137350 (View on PubMed)

Hunt JM. The cardiac surgical patient's expectations and experiences of nursing care in the intensive care unit. Aust Crit Care. 1999 Jun;12(2):47-53. doi: 10.1016/s1036-7314(99)70535-7.

Reference Type RESULT
PMID: 10624186 (View on PubMed)

Peterson JF, Pun BT, Dittus RS, Thomason JW, Jackson JC, Shintani AK, Ely EW. Delirium and its motoric subtypes: a study of 614 critically ill patients. J Am Geriatr Soc. 2006 Mar;54(3):479-84. doi: 10.1111/j.1532-5415.2005.00621.x.

Reference Type RESULT
PMID: 16551316 (View on PubMed)

Irish JT. Deciphering the physician-older patient interaction. Int J Psychiatry Med. 1997;27(3):251-67. doi: 10.2190/CQ97-Y82H-6P2E-9BJ4.

Reference Type RESULT
PMID: 9565727 (View on PubMed)

Gustafson Y, Berggren D, Brannstrom B, Bucht G, Norberg A, Hansson LI, Winblad B. Acute confusional states in elderly patients treated for femoral neck fracture. J Am Geriatr Soc. 1988 Jun;36(6):525-30. doi: 10.1111/j.1532-5415.1988.tb04023.x.

Reference Type RESULT
PMID: 2897391 (View on PubMed)

Micek ST, Anand NJ, Laible BR, Shannon WD, Kollef MH. Delirium as detected by the CAM-ICU predicts restraint use among mechanically ventilated medical patients. Crit Care Med. 2005 Jun;33(6):1260-5. doi: 10.1097/01.ccm.0000164540.58515.bf.

Reference Type RESULT
PMID: 15942341 (View on PubMed)

Kamdar BB, Needham DM, Collop NA. Sleep deprivation in critical illness: its role in physical and psychological recovery. J Intensive Care Med. 2012 Mar-Apr;27(2):97-111. doi: 10.1177/0885066610394322. Epub 2011 Jan 10.

Reference Type RESULT
PMID: 21220271 (View on PubMed)

Gabor JY, Cooper AB, Crombach SA, Lee B, Kadikar N, Bettger HE, Hanly PJ. Contribution of the intensive care unit environment to sleep disruption in mechanically ventilated patients and healthy subjects. Am J Respir Crit Care Med. 2003 Mar 1;167(5):708-15. doi: 10.1164/rccm.2201090.

Reference Type RESULT
PMID: 12598213 (View on PubMed)

Bross MH, Tatum NO. Delirium in the elderly patient. Am Fam Physician. 1994 Nov 1;50(6):1325-32.

Reference Type RESULT
PMID: 7942430 (View on PubMed)

Other Identifiers

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2014-0251

Identifier Type: -

Identifier Source: org_study_id

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