Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
22 participants
INTERVENTIONAL
2015-09-30
2016-05-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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Change in physical activity for older adults
Older adult participants undergo alterations in daily ambulation by completing Normal Daily Steps for one week, followed by a two-week Step-Reduction and a subsequent Return to Normal Daily Steps for two weeks
Normal Daily Steps
Complete normal daily ambulation for one week
Step-Reduction
Reduce daily ambulation to fewer than 1000 steps per day for two weeks
Return to Normal Daily Steps
Increase daily ambulation to 100% of normal daily step-count for two weeks
Interventions
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Normal Daily Steps
Complete normal daily ambulation for one week
Step-Reduction
Reduce daily ambulation to fewer than 1000 steps per day for two weeks
Return to Normal Daily Steps
Increase daily ambulation to 100% of normal daily step-count for two weeks
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Chronic use of analgesic or anti-inflammatory drugs
* History of neuromuscular problems or muscle and/or bone wasting disease
* Acute or chronic illness including cardiac, pulmonary, liver or kidney abnormalities, uncontrolled hypertension, insulin or non-insulin dependent diabetes or other metabolic disorders
* Daily use of statins, particularly simvastatin and atorvastatin
* Use of medications known to affect protein metabolism
* Normally complete fewer than 3000 steps per day
65 Years
80 Years
ALL
Yes
Sponsors
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Canadian Diabetes Association
OTHER
McMaster University
OTHER
Responsible Party
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Stuart Phillips
Professor
Locations
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Exercise Metabolism Research Laboratory, McMaster Univeristy
Hamilton, Ontario, Canada
Countries
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References
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Breen L, Stokes KA, Churchward-Venne TA, Moore DR, Baker SK, Smith K, Atherton PJ, Phillips SM. Two weeks of reduced activity decreases leg lean mass and induces "anabolic resistance" of myofibrillar protein synthesis in healthy elderly. J Clin Endocrinol Metab. 2013 Jun;98(6):2604-12. doi: 10.1210/jc.2013-1502. Epub 2013 Apr 15.
Devries MC, Breen L, Von Allmen M, MacDonald MJ, Moore DR, Offord EA, Horcajada MN, Breuille D, Phillips SM. Low-load resistance training during step-reduction attenuates declines in muscle mass and strength and enhances anabolic sensitivity in older men. Physiol Rep. 2015 Aug;3(8):e12493. doi: 10.14814/phy2.12493.
McGlory C, von Allmen MT, Stokes T, Morton RW, Hector AJ, Lago BA, Raphenya AR, Smith BK, McArthur AG, Steinberg GR, Baker SK, Phillips SM. Failed Recovery of Glycemic Control and Myofibrillar Protein Synthesis With 2 wk of Physical Inactivity in Overweight, Prediabetic Older Adults. J Gerontol A Biol Sci Med Sci. 2018 Jul 9;73(8):1070-1077. doi: 10.1093/gerona/glx203.
Other Identifiers
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0574
Identifier Type: -
Identifier Source: org_study_id
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