A Phase II Dose-escalation Study Characterizing the PK of Eltrombopag in Pediatric Patients With Previously Untreated or Relapsed Severe Aplastic Anemia or Recurrent Aplastic Anemia

NCT ID: NCT03025698

Last Updated: 2025-03-04

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE2
• Total Enrollment: 51 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2017-09-30
• Study Completion Date: 2025-01-27

Brief Summary

This is a phase II, open label, multi-center, intra-patient dose escalation study to characterize the pharmacokinetics (PK) after oral administration of eltrombopag in combination with immunosuppressive therapy in pediatric patients with previously untreated or relapsed/refractory severe aplastic anemia or recurrent aplastic anemia.

Detailed Description

All patients were treated with eltrombopag for the 26-week Treatment Period, followed by a 52-week Follow-Up Period. Patients who had been previously untreated with immunosuppressive therapy were treated according to the standard of care, hATG/cyclosporine, in addition to eltrombopag. Patients with relapsed/refractory SAA or recurrent AA were enrolled into one of two treatment options: hATG/cyclosporine plus eltrombopag or cyclosporine plus eltrombopag, depending on prior treatment with immunosuppressive therapy. Patients could receive eltrombopag beyond 26 weeks if the investigator thought that the patient was still receiving clinical benefit from the drug.

After initiating treatment with eltrombopag, patients had their dose assessed and modified as tolerated, until the targeted platelet count or maximum dose was achieved. Pharmacokinetic assessments were performed at time points intended to capture steady state PK of the starting dose and highest dose achieved.

There are four separate periods of this study: Screening (signing of written informed consent through Day -1), Treatment (for 26 weeks), Follow-up (additional 52 weeks), and Long-term Follow-up (for additional 3 years). The first 3 periods were considered the Core phase of the study.

Study completion (Core) will occur when the last patient completes the 26-week treatment and 52-week Follow-up Period [at Week 78].

Conditions

Aplastic Anemia

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Cohort A (Option 1)

Regimen 1: hATG (ATGAM®), CsA and eltrombopag begin on Day 1.

Group Type: EXPERIMENTAL

Eltrombopag

Intervention Type: DRUG

Tablet for oral use, once daily or Powder for oral suspension (PfOS), once daily

hATG

Intervention Type: DRUG

Horse ATG (ATGAM) (hATG) is not considered an investigational medicinal product (IMP)

CsA

Intervention Type: DRUG

Cyclosporine (CsA) will be by supplied as either oral capsules or oral solution, administered twice a day

Cohort A (option 2)

CsA and eltrombopag begin on Day 1.

Group Type: EXPERIMENTAL

Eltrombopag

Intervention Type: DRUG

Tablet for oral use, once daily or Powder for oral suspension (PfOS), once daily

CsA

Intervention Type: DRUG

Cyclosporine (CsA) will be by supplied as either oral capsules or oral solution, administered twice a day

Cohort B

previously untreated SAA, hATG (ATGAM®), CsA and eltrombopag begin on Day 1 and all patients will be treated with the same regimen

Group Type: EXPERIMENTAL

Eltrombopag

Intervention Type: DRUG

Tablet for oral use, once daily or Powder for oral suspension (PfOS), once daily

hATG

Intervention Type: DRUG

Horse ATG (ATGAM) (hATG) is not considered an investigational medicinal product (IMP)

CsA

Intervention Type: DRUG

Cyclosporine (CsA) will be by supplied as either oral capsules or oral solution, administered twice a day

Interventions

Eltrombopag

Tablet for oral use, once daily or Powder for oral suspension (PfOS), once daily

Intervention Type: DRUG

hATG

Horse ATG (ATGAM) (hATG) is not considered an investigational medicinal product (IMP)

Intervention Type: DRUG

CsA

Cyclosporine (CsA) will be by supplied as either oral capsules or oral solution, administered twice a day

Intervention Type: DRUG

Other Intervention Names

ETB115

Eligibility Criteria

Inclusion Criteria

For Cohort A patients:

• History of prior diagnosis of SAA,
• Diagnosis of relapsed/refractory SAA or recurrent AA following treatment for SAA, as per Section 5.1. Patients with recurrent AA (e.g., losing their response) are exempt from meeting the diagnostic criteria for SAA relapse at the time of study enrollment, but must have been previously diagnosed with SAA.
• Agree to concurrent eltrombopag treatment with appropriate, investigator-selected Immunosuppressive therapy (IST) with either hATG + CsA or CsA.

For Cohort B patients:

• Diagnosis of SAA at time of enrollment.
• Patients must not have been previously treated with IST, and must meet all criteria as described in Table 5-1.
• Patients must agree to treatment with hATG + CsA concurrent with eltrombopag.

All patients eligible for inclusion in this study must meet all of the following criteria:

• Age 1 to <18 years.
• Assessments to rule out congenital/inherited bone marrow failure syndromes and other causes of immune-mediated pancytopenia, which may be treated with transplant, must be completed prior to enrollment.
• Hematopoietic stem cell transplantation (HSCT) is not suitable or available as a treatment option or has been refused by the patient. (Candidacy for HSCT will be determined as per local practices or national guidelines.)
• Bone marrow aspirate and biopsy at any time during the 4 weeks prior to first dose of eltrombopag.
• Performance status score: Karnofsky ≥50 for patients 16 years of age and older or Lansky ≥50 for patients below 16 years of age.
• Written informed consent must be signed by a parent or legal guardian prior to initiation of any study specific procedure.
• Normal karyotype within 4 weeks prior to first dose of eltrombopag. If there are insufficient metaphases (< 10) to determine karyotype, a repeat marrow aspirate is required. If upon repeat bone marrow aspirate, the number of metaphases is insufficient (< 10), then FISH probes performed in marrow aspirate as per protocol must be normal.

Exclusion Criteria

• Prior and/or active medical history of:

• Fanconi anemia (via chromosome breakage test or growth arrest by flow cytometry)
• Other known underlying inherited marrow failure syndrome (such as but not limited to Dyskeratosis Congenita, Congenital Amegakaryocytic Thrombocytopenia, or Shwachman-Diamond Syndrome).
• Symptomatic Paroxysmal Nocturnal Hemoglobinuria (PNH) and/or PNH clones >50% of White blood cell (WBC) or Red blood cell (RBC) at time of enrollment.

• Any cytogenetic abnormalities by karyotyping or FISH.
• Myelodysplastic syndrome (MDS)
• Other known or suspected underlying primary immunodeficiency
• Any malignancy
• Active infection not responding to appropriate therapy.
• Prior eltrombopag or other thrombopoietin receptor (TPO-R) agonist treatment for at least 2 months and a lack of response.
• Have any of the following out-of-range laboratory values:

• Serum Creatinine >2.5 × upper limit of normal (ULN),
• Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) >3 × ULN.
• Concurrent participation in an investigational study within 30 days prior to enrollment or within 5-half-lives of the investigational product, whichever is longer. Note: a parallel enrollment in a registry for patients with SAA or AA is acceptable.

Pregnant or nursing (lactating) women.

• Female patients of childbearing potential (e.g., are menstruating or could reach menarche during the study, this usually includes girls 9 years and older) who do not agree to abstinence or, if sexually active, do not agree to the use of contraception as defined in Section 7.2.1.2.6 (pregnancy section) of the protocol. If local regulations are more stringent than the contraception methods listed in this protocol to prevent pregnancy, local regulations apply and will be described in the ICF.
• Male patients who are sexually active and do not agree to abstinence or to use a condom during intercourse while taking eltrombopag, and for 13 weeks after stopping treatment.
• Patients, who in the investigators' opinion may be unwilling, are unable or unlikely to comply with the requirements of the study protocol.
• Known immediate or delayed hypersensitivity reaction or idiosyncrasy to drugs chemically related to eltrombopag or its excipient, CSA, or hATG that contraindicates patient participation.
• History of major surgery, serious illness, or traumatic injury within 4 weeks of first dose of study treatment.
• Patients with known history of HIV positivity.
• Patients with known history of hepatitis B or C positivity.
• Any severe and/or uncontrolled medical conditions which could cause unacceptable safety risks or compromise compliance with the protocol, such as:

• Impairment of gastrointestinal function or gastrointestinal disease that may significantly alter the absorption of study drug (e.g., ulcerative disease, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome),Active skin, mucosa, ocular or GI disorders of Grade > 1.
• Impaired cardiac function, such as:

• Patients with a history of congenital long QT syndrome or known family history of long QTc syndrome,
• Corrected QTc >450 msec using Fridericia correction (QTcF) on the screening ECG (using triplicate ECGs),
• Ventricular arrhythmias and or other cardiac arrhythmia not controlled with medication,
• Other clinically significant cardio-vascular disease (e.g., congestive heart failure, uncontrolled hypertension, history of labile hypertension),
• History of known structural abnormalities (e.g., cardiomyopathy).

• Minimum Eligible Age: 1 Year
• Maximum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Novartis Pharmaceuticals

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Novartis Pharmaceuticals

Role: STUDY_DIRECTOR

Novartis Pharmaceuticals

Locations

Phoenix Children s Hospital

Phoenix, Arizona, United States

Arkansas Childrens Hospital

Little Rock, Arkansas, United States

Childrens Hospital Colorado

Aurora, Colorado, United States

Aflac Cancerand Blood Disorders Ctr

Atlanta, Georgia, United States

Ann and Robert H Lurie Childrens Hospital of Chicago

Chicago, Illinois, United States

Indiana University

Indianapolis, Indiana, United States

Childrens Hosp Boston Dept of Hematology

Boston, Massachusetts, United States

University of MI Health System

Ann Arbor, Michigan, United States

Hackensack University Medical Center SC-2

Hackensack, New Jersey, United States

Duke University Medical Center

Durham, North Carolina, United States

Cleveland Clinic Foundation

Cleveland, Ohio, United States

Texas Children's Cancer and Hematology Center

Houston, Texas, United States

Novartis Investigative Site

Shatin, , Hong Kong

Novartis Investigative Site

Lisbon, , Portugal

Novartis Investigative Site

Moscow, , Russia

Novartis Investigative Site

Saint Petersburg, , Russia

Novartis Investigative Site

Khon Kaen, THA, Thailand

Novartis Investigative Site

Bangkok, , Thailand

Novartis Investigative Site

Bangkok, , Thailand

Novartis Investigative Site

London, , United Kingdom

Countries

United States; Hong Kong; Portugal; Russia; Thailand; United Kingdom

References

Shimamura A, Maschan A, Bennett C, Samarasinghe S, Farrar JE, Li CK, Sirachainan N, Pongtanakul B, Komvilaisak P, Zubarovskaya L, Rothman JA, Walkovich K, Nakano TA, Bertuch AA, Ferrao A, Bhat R, Hanna R, Overholt K, Boklan J, Wong TF, Wang Q, Urban P, Strahm B, Wang W, Vlachos A, Williams DA. Eltrombopag in combination with immunosuppressive therapy in pediatric severe aplastic anemia: phase 2 ESCALATE trial. Blood Adv. 2025 Aug 12;9(15):3728-3738. doi: 10.1182/bloodadvances.2024015102.

Reference Type: DERIVED

PMID: 40315366 (View on PubMed)

Other Identifiers

CETB115E2201

Identifier Type: -

Identifier Source: org_study_id