Bypass vs. Ecmo in Lung Transplantation (BELT)

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

13 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-04-17

Study Completion Date

2019-01-24

Brief Summary

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This study seeks to compare outcomes of 2 different methods of cardiopulmonary support during lung transplant surgeries.

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Detailed Description

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This study will compare use of extracorporeal membrane oxygenation (ECMO) and heart-lung bypass (CPB) during lung transplant procedures and their short and long term outcomes.

Conditions

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Lung Transplant; Complications

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Cardiopulmonary Bypass

There will be 40 patients placed on cardiopulmonary bypass during lung transplantation.

Cardiopulmonary Bypass

Intervention Type DEVICE

CPB is used during lung transplant procedure

Extracorporeal Membrane Oxygenation

There will be 40 patients placed on ECMO during lung transplantation.

Extracorporeal Membrane Oxygenation

Intervention Type DEVICE

ECMO is used during lung transplant procedure

Interventions

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Extracorporeal Membrane Oxygenation

ECMO is used during lung transplant procedure

Intervention Type DEVICE

Cardiopulmonary Bypass

CPB is used during lung transplant procedure

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1\. The study population will be all patients requiring cardiopulmonary support while undergoing lung transplantation at our institution.

Exclusion Criteria

1. Patients undergoing concomitant cardiac operations with indication for obligate use of cardiopulmonary bypass
2. Patient with specific anatomy that require full cardiac decompression such as severe pulmonary hypertension or large heart that are shifted severely into the left chest
3. Patients with high likelihood of significant pleural bleeding that will require returning the blood back into the cardiotomy reservoir
4. Patients bridged to transplant with ECMO
5. Cystic fibrosis/bronchiectasis/resistant infection patients where surgeon will need to remove both lungs prior to implantation
6. Patients who the surgeon feels would be better served with CPB rather than ECMO- These patients will be entered into a registry and followed.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No