Metabolic Profiling of Type 1 Diabetes Mellitus in Children and Adolescents
NCT ID: NCT03014908
Last Updated: 2017-01-09
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
14 participants
OBSERVATIONAL
2014-01-31
2014-12-31
Brief Summary
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Detailed Description
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This cross-sectional study was set-up to examine the metabolic profile in fasting plasma samples from 7 T1DM children and 7 non-diabetic controls aged 8 to 18 years, and matched for gender, age and BMI. The obtained plasma 1H-NMR spectra were rationally divided into 110 integration regions, representing the metabolic phenotype. These integration regions reflect the relative metabolite concentrations and were used as statistical variables to construct (train) a classification model in discriminating between T1DM patients and controls.
Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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NMR-T1DM
type 1 diabetic children and adolescents
Blood sampling
Determine the metabolic phenotype of blood plasma by proton-NMR spectroscopy
NMR-C
non-diabetic children and adolescents
Blood sampling
Determine the metabolic phenotype of blood plasma by proton-NMR spectroscopy
Interventions
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Blood sampling
Determine the metabolic phenotype of blood plasma by proton-NMR spectroscopy
Eligibility Criteria
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Inclusion Criteria
* normal-weight according to the International Obesity Task Force (IOTF) BMI criteria
* fasted for at least 8 hours.
Exclusion Criteria
8 Years
18 Years
ALL
Yes
Sponsors
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Jessa Hospital
OTHER
Hasselt University
OTHER
Responsible Party
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Peter Adriaensens
professor (hoogleraar)
Principal Investigators
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Peter Adriaensens, PhD
Role: PRINCIPAL_INVESTIGATOR
Institute of Material Research, Hasselt University
Guy Massa, PhD, MD
Role: STUDY_CHAIR
Jessa Ziekenhuis Hasselt
Wanda Guedens, PhD
Role: STUDY_CHAIR
Hasselt University
Evelyne Louis, PhD
Role: STUDY_CHAIR
Hasselt University
Jean-Paul Noben, PhD
Role: STUDY_CHAIR
Hasselt University
Liene Bervoets, PhD
Role: STUDY_CHAIR
Hasselt University
Locations
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Hasselt University
Hasselt, Limburg, Belgium
Countries
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References
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Beckonert O, Keun HC, Ebbels TM, Bundy J, Holmes E, Lindon JC, Nicholson JK. Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts. Nat Protoc. 2007;2(11):2692-703. doi: 10.1038/nprot.2007.376.
Brugnara L, Mallol R, Ribalta J, Vinaixa M, Murillo S, Casserras T, Guardiola M, Vallve JC, Kalko SG, Correig X, Novials A. Improving Assessment of Lipoprotein Profile in Type 1 Diabetes by 1H NMR Spectroscopy. PLoS One. 2015 Aug 28;10(8):e0136348. doi: 10.1371/journal.pone.0136348. eCollection 2015.
Lanza IR, Zhang S, Ward LE, Karakelides H, Raftery D, Nair KS. Quantitative metabolomics by H-NMR and LC-MS/MS confirms altered metabolic pathways in diabetes. PLoS One. 2010 May 10;5(5):e10538. doi: 10.1371/journal.pone.0010538.
Other Identifiers
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LCRP-obesitas
Identifier Type: -
Identifier Source: org_study_id
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