Endoscopic Ultrasound (EUS) Fine Needle Biopsy (FNB) Submucosal Nodule

NCT ID: NCT03011229

Last Updated: 2020-05-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

2017-09-05

Study Completion Date

2019-09-30

Brief Summary

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The purpose of this study is to compare the diagnostic accuracy of a novel endoscopic ultrasound (EUS) biopsy needle to the current standard EUS needle.

The investigators hypothesize that with the SharkcoreTM needle a diagnostic yield of 90% is possible for subepithelial lesions (SEL) within the Gastrointestinal (GI) tract versus 60% yield with the current needle.

Detailed Description

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Conditions

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GI Lesions

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Pro Core

Subject is randomized to ProCore standard needle.

Group Type ACTIVE_COMPARATOR

Pro Core Needle

Intervention Type DEVICE

Needle will be used in standard fashion utilizing a slow pull technique by an expert endoscopist who is familiar with EUS and use of both needles.

Medtronic Shark Core

Subject is randomized to Medtronic Sharkcore needle

Group Type EXPERIMENTAL

medtronic Sharkcore Needle

Intervention Type DEVICE

Needle will be used in standard fashion utilizing a slow pull technique by an expert endoscopist who is familiar with EUS and use of both needles.

Interventions

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Pro Core Needle

Needle will be used in standard fashion utilizing a slow pull technique by an expert endoscopist who is familiar with EUS and use of both needles.

Intervention Type DEVICE

medtronic Sharkcore Needle

Needle will be used in standard fashion utilizing a slow pull technique by an expert endoscopist who is familiar with EUS and use of both needles.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Patients age 18 or older referred for EUS found to have a hypoechoic lesion \> 8 mm within the GI lumen arising from the muscularis propria, as determined by EUS.
* Women that have a negative pregnant test

Exclusion Criteria

* Patients under the age of 18.
* Uncorrectable coagulopathy (INR\>1.5)
* Uncorrectable thrombocytopenia (platelet count \<50,000)
* Patient who is unable to comply with study requirements
* Pregnant women
* Female patients who are not tested per our current unit protocol
* Refusal to consent or unable to provide informed consent
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Duke University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Joshua Spaete

Role: PRINCIPAL_INVESTIGATOR

Duke Health System

Locations

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Duke

Durham, North Carolina, United States

Site Status

Countries

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United States

Other Identifiers

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Pro00077315

Identifier Type: -

Identifier Source: org_study_id

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