Letrozole Versus Laparoscopic Ovarian Drilling in Polycystic Ovary Syndrome
NCT ID: NCT03009838
Last Updated: 2022-05-09
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE3
150 participants
INTERVENTIONAL
2017-01-02
2023-08-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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letrozole
letrozole 2.5 mg oral tablets will be started daily from day 3 of the menses for 5 days in a dose of 5 mg/day
Letrozole
oral tablets 2.5 mg
laparoscopic drilling
laparoscopy will be performed using three-puncture technique. Each ovary will be cauterized at four points, each for 4 seconds at 40 W for a depth of 4 mm with a mixed current, using a monopolar electrosurgical needle
ovarian drilling
laparoscopic electrocauterization
Interventions
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Letrozole
oral tablets 2.5 mg
ovarian drilling
laparoscopic electrocauterization
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Body mass index: 25-35
* Normal fallopian tubes
* Normal semen analysis of the husband
* Women who will accept to participate in the study
Exclusion Criteria
* Contraindication to general anesthesia
* Previous laparoscopic drilling
* Presence of other causes of infertility
* Women who had received metformin, gonadotrophin, oral contraceptives or other hormonal drugs during the preceding 6 months
* Women who intended to start a diet program
* Women who will refuse to participate in the study.
20 Years
35 Years
FEMALE
No
Sponsors
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Assiut University
OTHER
Responsible Party
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Ahmed Mohamed Abbas
Dr.
Locations
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Assiut University
Asyut, , Egypt
Countries
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Central Contacts
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Facility Contacts
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Ahmed Abbas, MD
Role: primary
References
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Franik S, Le QK, Kremer JA, Kiesel L, Farquhar C. Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome. Cochrane Database Syst Rev. 2022 Sep 27;9(9):CD010287. doi: 10.1002/14651858.CD010287.pub4.
Other Identifiers
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LEVOD
Identifier Type: -
Identifier Source: org_study_id
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