Ischemic Memory Imaging With Myocardial Contrast Echocardiography
NCT ID: NCT03009266
Last Updated: 2018-08-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
EARLY_PHASE1
40 participants
INTERVENTIONAL
2018-07-07
2019-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
DIAGNOSTIC
NONE
Study Groups
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Normal controls
Normal controls who will undergo dose-ranging studies to determine the optimal dose of phosphatidylserine-containing microbubbles that does not produce delayed myocardial opacification on myocardial contrast echocardiography (MCE).
Sonazoid
Myocardial contrast echocardiography ischemic memory imaging using intravenous administration of Sonazoid
Patients with ACS
Subjects with ACS who have undergone primary percutaneous intervention in whom MCE with phosphatidylserine-containing microbubbles will be performed to determine whether the risk area can be detected and spatially defined.
Sonazoid
Myocardial contrast echocardiography ischemic memory imaging using intravenous administration of Sonazoid
Interventions
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Sonazoid
Myocardial contrast echocardiography ischemic memory imaging using intravenous administration of Sonazoid
Eligibility Criteria
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Inclusion Criteria
* Patients with diagnosis of acute coronary syndrome with either unstable angina or non-ST-elevation MI
* Referred for primary percutaneous intervention
* At least 1 high risk features (ST changes, positive troponin, wall motion abnormality)
Exclusion Criteria
* allergy to eggs or ultrasound contrast agents
* known or detected right to left shunt
* presence of a wall motion abnormality
* pregnancy
ACS GROUP
* allergy to eggs or ultrasound contrast agents
* hemodynamic instability or shock
* known or detected right to left shunt
* pregnancy
* multivessel CAD requiring multivessel PCI
19 Years
90 Years
ALL
Yes
Sponsors
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Oregon Health and Science University
OTHER
Responsible Party
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Jonathan R. Lindner, MD
Professor
Locations
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OHSU
Portland, Oregon, United States
Countries
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Central Contacts
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Facility Contacts
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References
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Davidson BP, Hodovan J, Layoun ME, Golwala H, Zahr F, Lindner JR. Echocardiographic Ischemic Memory Molecular Imaging for Point-of-Care Detection of Myocardial Ischemia. J Am Coll Cardiol. 2021 Nov 16;78(20):1990-2000. doi: 10.1016/j.jacc.2021.08.068.
Other Identifiers
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IRB00016794
Identifier Type: -
Identifier Source: org_study_id
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