Evaluation of a Smartphone Based Optical Diagnostic Tool for Neonatal Jaundice

NCT ID: NCT03007563

Last Updated: 2020-04-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

342 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-01-31

Study Completion Date

2019-03-15

Brief Summary

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Neonatal jaundice is a common and most often harmless condition. However, when unrecognized it can be fatal or cause serious brain injury. Three quarters of these deaths are estimated to occur in the poorest regions of the world. The treatment of jaundice, phototherapy, is in most cases easy, low-cost and harmless. The crucial point in reducing the burden of disease is therefore to identify then children at risk. This results in the need for low-cost, reliable and easy-to-use diagnostic tools that can identify newborns with jaundice.

Based on previous research on the bio-optics of jaundiced newborn skin, a prototype of a smartphone application has been developed. This prototype will be evaluated in a clinical trial in two hospitals in Norway. A smartphone will be used to take picture of the skin of the newborn, and by using an algorithm an estimate of the bilirubin concentration is made. The results from these estimates will be compared to the bilirubin levels measured in standard blood samples, as well as the results from ordinary transcutaneous measurement devices.

Detailed Description

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Conditions

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Jaundice, Neonatal Hyperbilirubinemia, Neonatal

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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newborn infants checked for jaundice

an experimental way of bilirubin concentration estimation from smartphone pictures is applied and compared with two standard methods: bilirubin concentration measured in standard blood samples, and bilirubin concentration measured by transcutaneous device.

Group Type EXPERIMENTAL

bilirubin concentration estimation from smartphone pictures

Intervention Type DEVICE

pictures taken of the skin covering the breast bone

bilirubin concentration measured in standard blood samples

Intervention Type PROCEDURE

bilirubin concentration measured by transcutaneous device

Intervention Type DEVICE

Interventions

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bilirubin concentration estimation from smartphone pictures

pictures taken of the skin covering the breast bone

Intervention Type DEVICE

bilirubin concentration measured in standard blood samples

Intervention Type PROCEDURE

bilirubin concentration measured by transcutaneous device

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* born in St.Olavs hospital, Trondheim or in Akershus hospital, Oslo, Norway
* born at term
* normal birth weight

Exclusion Criteria

* in need of advanced medical treatment
Minimum Eligible Age

1 Day

Maximum Eligible Age

14 Days

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Norwegian University of Science and Technology

OTHER

Sponsor Role collaborator

University Hospital, Akershus

OTHER

Sponsor Role collaborator

St. Olavs Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Siri Forsmo, md prof

Role: STUDY_DIRECTOR

Norwegian University of Science and Technology

Locations

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Akershus University Hospital

Oslo, , Norway

Site Status

St Olavs Hospital

Trondheim, , Norway

Site Status

Countries

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Norway

References

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Aune A, Vartdal G, Bergseng H, Randeberg LL, Darj E. Bilirubin estimates from smartphone images of newborn infants' skin correlated highly to serum bilirubin levels. Acta Paediatr. 2020 Dec;109(12):2532-2538. doi: 10.1111/apa.15287. Epub 2020 Apr 19.

Reference Type RESULT
PMID: 32267569 (View on PubMed)

Other Identifiers

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2014/619

Identifier Type: -

Identifier Source: org_study_id

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