BUBOLight®, a New Phototherapy Device for the Treatment of the Newborn's Jaundice

NCT ID: NCT04365998

Last Updated: 2025-12-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-10-08

Study Completion Date

2026-12-31

Brief Summary

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About 50% of full-term newborns and 80% of premature infants develop jaundice which is due to hyperbilirubinemia. In the majority of cases, jaundice disappears naturally without treatment within three weeks of birth, but the bilirubin level may remain too high, which can lead to a serious neurological disease: kernicterus. To avoid this, a therapeutic management must be instituted, and in some cases, one or more phototherapy sessions (PT) may be prescribed.

The aim of this trial is to evaluate the safety and level of satisfaction of parents and healthcare team with one innovative device for phototherapy BUBOLight® included two removable strips of luminous textile incorporating optical fibers.

10 newborns requiring phototherapy, will be illuminated during four hours in one session of PT Bilirubin levels is taken at the start of phototherapy H0 and Controls are made at H+6 hours.

Detailed Description

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Conditions

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Neonatal Jaundice

Keywords

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jaundice phototherapy medical device newborn

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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BUBOLight® Device

Group Type EXPERIMENTAL

BUBOLight® Device

Intervention Type DEVICE

1 session of phototherapy with BUBOLight® device during 4 hours.

Interventions

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BUBOLight® Device

1 session of phototherapy with BUBOLight® device during 4 hours.

Intervention Type DEVICE

Other Intervention Names

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Phototherapy device with light emitting fabrics.

Eligibility Criteria

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Inclusion Criteria

* At time of birth, infant is \> 35 weeks gestation
* Presence of jaundice confirmed by measurement of bilirubin (transcutaneous bilirubinometer)
* Total bilirubinemia rate requiring phototherapy according to National Institute for Health and Clinical Excellence.
* Weight ≥2.500kg
* Judged in good health by the investigator following the clinical examination and the medical data (absence of perinatal asphyxia, antibiotic treatment, respiratory disorders)
* Absence of fœto-maternal rhesus incompatibility or Kell

Exclusion Criteria

* Newborn already treated with phototherapy
* Febrile state with body temperature \> 37.8°C
* Total bilirubinaemia level is equal or excess 100 μmol / L of the indication of phototherapy.
* Patient whose jaundice is due to haemolysis, obstruction functional or anatomical.
* Minor relative
* Newborn requiring exchange transfusion
* Newborn with congenital erythropoietic porphyria or a family history of porphyria.
* Patient requiring treatment other than phototherapy
Maximum Eligible Age

30 Days

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Institut National de la Santé Et de la Recherche Médicale, France

OTHER_GOV

Sponsor Role collaborator

University Hospital, Lille

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Thameur Rakza, MD

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Lille

Locations

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Hop Jeanne de Flandre Chu Lille

Lille, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Thameur Rakza, MD

Role: CONTACT

Phone: 03 20 44 63 87

Email: [email protected]

Serge Mordon, PhD

Role: CONTACT

Email: [email protected]

Facility Contacts

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Role: primary

References

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Lecomte F, Thecua E, Ziane L, Deleporte P, Duhamel A, Vamour C, Mordon S, Rakza T. Phototherapy Using a Light-Emitting Fabric (BUBOLight) Device in the Treatment of Newborn Jaundice: Protocol for an Interventional Feasibility and Safety Study. JMIR Res Protoc. 2021 May 25;10(5):e24808. doi: 10.2196/24808.

Reference Type RESULT
PMID: 34032584 (View on PubMed)

Other Identifiers

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2019-A01417-50

Identifier Type: OTHER

Identifier Source: secondary_id

2018_68

Identifier Type: -

Identifier Source: org_study_id