Effectiveness and Handling of Spiolto® Respimat ® in COPD Patients - Italy

NCT ID: NCT03003494

Last Updated: 2019-09-30

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

306 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-06-06

Study Completion Date

2018-07-30

Brief Summary

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The purpose of the study is to measure changes in physical functioning in chronic obstructive pulmonary disease (COPD) patients being treated with Spiolto® Respimat® after approximately 6 weeks in routine clinical practice.

Detailed Description

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Purpose:

Conditions

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Pulmonary Disease, Chronic Obstructive

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Spiolto® Respimat®

consented COPD patients who will be treated with Spiolto® Respimat® according to the approved SmPC

Spiolto® Respimat®

Intervention Type DRUG

observations taken in a period of approximately 6 weeks

Interventions

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Spiolto® Respimat®

observations taken in a period of approximately 6 weeks

Intervention Type DRUG

Other Intervention Names

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INSPIOLTO, SPIOLTO, STIOLTO, VAHELVA, YANIMO

Eligibility Criteria

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Inclusion Criteria

1. Written informed consent prior to participation
2. Female and male patients = 40 years of age
3. Patients diagnosed with COPD and requiring long-acting dual bronchodilation (LAMA + LABA) treatment according to approved Spiolto® Respimat® SmPC and therapeutic plan recommendation

Exclusion Criteria

1. Patients with contraindications according to Spiolto® Respimat® Summary of Product Characteristics (SmPC)
2. Patients who have been treated with a LABA/LAMA combination (free and fixed dose) in the previous 6 months
3. Patients continuing LABA-Inhalative Corticosteroids (ICS) treatment should not be additionally treated with Spiolto® Respimat® in order to avoid a double dosing of long-acting beta-agonists
4. Patients for whom further follow-up is not possible at the enrolling site during the planned study period of approx. 6 weeks
5. Pregnancy and lactation
6. Patients currently listed for lung transplantation
7. Current participation in any clinical trial or any other non-interventional study of a drug or device
Minimum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Boehringer Ingelheim

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Boehringer Ingelheim

Role: STUDY_CHAIR

Boehringer Ingelheim

Locations

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Ospedale Generale Regionale "Miulli"

Acquaviva Delle Fonti (BA), , Italy

Site Status

Azienda Ospedaliera G. Rummo

Benevento, , Italy

Site Status

Casa di cura Mons. Calaciura

Biancavilla, , Italy

Site Status

Ospedale Orlandi

Bussolengo (VR), , Italy

Site Status

IRCCS - Istituto Scientifico di Cassano delle Murge

Cassano Murge Bari, , Italy

Site Status

Università degli Studi "Magna Grecia" - Campus "S. Venuta"

Catanzaro, , Italy

Site Status

Ospedale Mellino Mellini

Chiari (BS), , Italy

Site Status

Osp. Piero Palagi

Florence, , Italy

Site Status

Ospedale Colonnello D Avanzo

Foggia, , Italy

Site Status

A.O. Ospedale Guido Salvini

Garbagnate Milanese, , Italy

Site Status

Presidio Ospedaliero di Imperia - ASL 1 Imperiese

Imperia, , Italy

Site Status

Ospedale della Versilia

LIDO DI Camaiore (LU), , Italy

Site Status

Ospedale S. Salvatore

L’Aquila, , Italy

Site Status

Osp.dell'Angelo

Mestre, , Italy

Site Status

Fondazione Centro San Raffaele del Monte Tabor

Milan, , Italy

Site Status

ASST Grande Ospedale Metropolitano Niguarda

Milan, , Italy

Site Status

Osp. dei Colli Monaldi-Cotugno

Napoli, , Italy

Site Status

Azienda Sanitaria Ospedale S. Luigi Gonzaga

Orbassano, , Italy

Site Status

Azienda Ospedaliera Universitaria di Padova

Padua, , Italy

Site Status

Ospedale S.Maria della Misericordia, AO di Perugia

Perugia, , Italy

Site Status

Azienda Ospedali Riuniti Marche Nord

Pesaro, , Italy

Site Status

Az.per Assist. Sanitaria N.5 Friuli Occidentale

Pordenone, , Italy

Site Status

Azienda Ospedaliera Sant'Andrea-Università di Roma La Sapienza

Roma, , Italy

Site Status

Università di Salerno

Salerno, , Italy

Site Status

Presidio Ospedaliero di Sesto S. Giovanni ASST Nord Milano

Sesto San Giovanni (MI), , Italy

Site Status

Fondazione Salvatore Maugeri

Tradate (VA), , Italy

Site Status

Ospedale di Cattinara

Trieste, , Italy

Site Status

Auxilium Vitae

Volterra, , Italy

Site Status

Countries

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Italy

References

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Carone M, Pennisi A, D'Amato M, Donati AF, Ricci A, Scognamillo C, Chun L, Aliani M, Ronsivalle V, Pelaia G. Physical Functioning in Patients with Chronic Obstructive Pulmonary Disease Treated with Tiotropium/Olodaterol Respimat in Routine Clinical Practice in Italy. Pulm Ther. 2020 Dec;6(2):261-274. doi: 10.1007/s41030-020-00122-9. Epub 2020 Jun 18.

Reference Type DERIVED
PMID: 32557394 (View on PubMed)

Provided Documents

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Document Type: Statistical Analysis Plan

View Document

Document Type: Study Protocol

View Document

Other Identifiers

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1237.43

Identifier Type: -

Identifier Source: org_study_id

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