Bioavailability Study of SPARC001(Study 1) in Healthy Adult Volunteers

NCT ID: NCT02991222

Last Updated: 2019-05-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-01-15

Study Completion Date

2017-04-30

Brief Summary

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The objective of the study is to determine the relative bioavailability, safety and tolerability of SPARC001 and Reference001 in healthy, adult, male and female subjects

Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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SPARC001 type I

Treatment type I

Group Type EXPERIMENTAL

SPARC001 type I

Intervention Type DRUG

Treatment type I

SPARC001 type II

Intervention Type DRUG

Treatment type II

Reference001 type I

Intervention Type DRUG

Hydrocodone-Acetaminophen

Reference001 type II

Intervention Type DRUG

Hydrocodone-Acetaminophen

SPARC001 type II

Treatment type II

Group Type EXPERIMENTAL

SPARC001 type I

Intervention Type DRUG

Treatment type I

SPARC001 type II

Intervention Type DRUG

Treatment type II

Reference001 type I

Intervention Type DRUG

Hydrocodone-Acetaminophen

Reference001 type II

Intervention Type DRUG

Hydrocodone-Acetaminophen

Reference001 type I

Treatment type I

Group Type ACTIVE_COMPARATOR

SPARC001 type I

Intervention Type DRUG

Treatment type I

SPARC001 type II

Intervention Type DRUG

Treatment type II

Reference001 type I

Intervention Type DRUG

Hydrocodone-Acetaminophen

Reference001 type II

Intervention Type DRUG

Hydrocodone-Acetaminophen

Reference type II

Treatment type II

Group Type ACTIVE_COMPARATOR

SPARC001 type I

Intervention Type DRUG

Treatment type I

SPARC001 type II

Intervention Type DRUG

Treatment type II

Reference001 type I

Intervention Type DRUG

Hydrocodone-Acetaminophen

Reference001 type II

Intervention Type DRUG

Hydrocodone-Acetaminophen

Interventions

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SPARC001 type I

Treatment type I

Intervention Type DRUG

SPARC001 type II

Treatment type II

Intervention Type DRUG

Reference001 type I

Hydrocodone-Acetaminophen

Intervention Type DRUG

Reference001 type II

Hydrocodone-Acetaminophen

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

1. Adult, male and female volunteers, 18 to 55 years of age, inclusive, at first Check-In Visit;
2. Body mass index (BMI) ≥18 to ≤30 kg/m2 and total body weight \>50 kg (110 lbs) at Screening
3. All female subjects must have a negative serum pregnancy test at Screening and at each Check-in Visit
4. Medically healthy on the basis of medical history

Exclusion Criteria

1. Females who are pregnant, lactating, or likely to become pregnant during the study
2. Life-time history and/or recent evidence of alcohol or drug/substance abuse disorder
3. Subjects with history or presence of significant cardiovascular, pulmonary, hepatic, gallbladder or biliary tract, renal, hematologic, gastrointestinal, endocrine, immunologic, dermatologic, neurologic, psychiatric disease, or active sexually transmitted disease
4. Subjects determined by the investigator to have any medical condition that could jeopardize their health or prejudice the results
Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Sun Pharma Advanced Research Company Limited

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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SPARC Site 01

Secaucus, New Jersey, United States

Site Status

Countries

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United States

Other Identifiers

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CLR_16_28

Identifier Type: -

Identifier Source: org_study_id

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