Lung Tissue Research Consortium

NCT ID: NCT02988388

Last Updated: 2019-03-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

247 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-02-23

Study Completion Date

2019-02-21

Brief Summary

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The LTRC will facilitate histopathological research of pulmonary diseases by collecting lung tissues from donors and preparing and distributing collections of tissue specimens to researchers within and outside the LTRC. Collections of specimens will be linked to individual clinical data appropriate to the particular disease. The primary goal of the LTRC is to identify participants with suspected lung cancer or metastatic disease who are willing to provide informed consent for research use of their specimens and data. Secondarily, the LTRC investigators intend to collect clinical data, limited exposure data, physiologic studies, and radiographic studies from these participants.

Detailed Description

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Conditions

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Chronic Obstructive Pulmonary Disease Interstitial Lung Disease

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Lung biopsy/lobectomy

Adults ages 21 or older who are undergoing lung surgery for suspected malignancy or metastases.

Lung biopsy/lobectomy

Intervention Type PROCEDURE

Lung biopsies and lobectomies are not experimental. Participants will undergo a lung biopsy or a lobectomy as part of standard of care.

Interventions

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Lung biopsy/lobectomy

Lung biopsies and lobectomies are not experimental. Participants will undergo a lung biopsy or a lobectomy as part of standard of care.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Adults ages 21 or older who are undergoing lung surgery for suspected malignancy or metastases.

Exclusion Criteria

* Diagnosis of cystic fibrosis or pulmonary hypertension.
* Any other condition that, in the judgment of the investigator, precludes participation.
* Failure to obtain written consent.
Minimum Eligible Age

21 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Heart, Lung, and Blood Institute (NHLBI)

NIH

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Tom Croxton

Role: STUDY_DIRECTOR

National Heart, Lung, and Blood Institute (NHLBI)

Locations

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University of Michigan

Ann Arbor, Michigan, United States

Site Status

Mayo Clinic Rochester

Rochester, Minnesota, United States

Site Status

Temple University

Philadelphia, Pennsylvania, United States

Site Status

University of Pittsburgh

Pittsburgh, Pennsylvania, United States

Site Status

Countries

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United States

References

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Allen RJ, Stockwell A, Oldham JM, Guillen-Guio B, Schwartz DA, Maher TM, Flores C, Noth I, Yaspan BL, Jenkins RG, Wain LV; International IPF Genetics Consortium. Genome-wide association study across five cohorts identifies five novel loci associated with idiopathic pulmonary fibrosis. Thorax. 2022 Aug;77(8):829-833. doi: 10.1136/thoraxjnl-2021-218577. Epub 2022 Jun 10.

Reference Type DERIVED
PMID: 35688625 (View on PubMed)

Other Identifiers

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LTR01

Identifier Type: -

Identifier Source: org_study_id

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