Mepivacaine vs. Bupivacaine Spinal Anesthetic in Total Knee Arthroplasty

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

32 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-12-31

Study Completion Date

2017-03-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to determine if a shorter-acting spinal anesthetic called mepivacaine has advantages over a longer-acting medication called bupivacaine.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Mepivacaine vs Bupivacaine Spinal Anesthesia for TKA

NCT06291727

Anesthesia, Spinal Arthroplasty, Replacement, Knee

COMPLETED PHASE4

Peripheral Nerve Blocks vs Periarticular Local Anesthetic Injection for Total Knee Arthroplasty (TKA)

NCT02223364

Total Knee Arthroplasty

COMPLETED PHASE4

Trial of Liposomal Bupivacaine for TKA

NCT05635916

Knee Replacement Total Knee Arthroplasty Post-Operative Pain

COMPLETED PHASE4

Pharmacokinetics and Safety of Bupivacaine HCl Spinal Block and EXPAREL Local Infiltration in Total Knee Arthroplasty

NCT02284386

Pain

COMPLETED PHASE4

Liposomal Bupivacaine Versus Continuous Peripheral Nerve Blocks for Analgesia Following Ankle Surgery

NCT06995352

Moderate-to-severely Painful Ankle Surgery

ENROLLING_BY_INVITATION PHASE4

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Different medications last for different amounts of time and can be changed depending on the length of the procedure. A short acting spinal is generally used for procedures lasting less than 90 minutes. A longer acting medication would be any that lasts longer than 90 minutes. These medications not only block the signals that travel along the pain nerves, they also prevent the signals that tell the patients muscles to move. This means that after a total knee replacement a patient may delayed in their ability to get up and start walking early after surgery. Walking early in the recovery has been shown to decrease the rate of pulmonary embolism and death. Ambulating early is also important to prevent loss of strength, constipation, pneumonia and urinary retention.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Anesthesia, Spinal Arthroplasty, Replacement, Knee Pain Management Early Ambulation Ambulatory Surgical Procedures

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Mepivacaine Spinal Anesthetic

Mepivacaine 3 mL intrathecal injection of 2% solution

Group Type EXPERIMENTAL

Mepivacaine

Intervention Type DRUG

This is a shorter acting spinal anesthetic as compared to the current standard of care at this institution.

Bupivacaine Spinal Anesthetic

Bupivacaine 12 mg of 8.25% solution

Group Type ACTIVE_COMPARATOR

Bupivacaine

Intervention Type DRUG

This is the current standard of care at this institution and many centers. This is a longer acting spinal anesthetic compared to the study drug.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Mepivacaine

This is a shorter acting spinal anesthetic as compared to the current standard of care at this institution.

Intervention Type DRUG

Bupivacaine

This is the current standard of care at this institution and many centers. This is a longer acting spinal anesthetic compared to the study drug.

Intervention Type DRUG

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

CAS Number: 96-88-8 Carbocaine Sensorcaine Marcaine CAS 38396-39-3

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Adult patients undergoing primary total knee arthroplasty

Exclusion Criteria

* Chronic opioid users
* Unable to give informed consent
* Forego the use of a foley catheter
* Those with hypersensitively to amide local anesthetics or opioids
* Those with contraindications to spinal anesthesia
* Conversion to general anesthesia will be excluded.

Minimum Eligible Age

40 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes