Local Infiltration With Bupivacaine to Increase Quality of Post-operative Pain Control in Total Knee Replacement
NCT ID: NCT01364194
Last Updated: 2011-06-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE4
60 participants
INTERVENTIONAL
2010-03-31
2010-09-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
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0.25% Bupivacaine
Periarticular injection with 20 ml of 0.25% bupivacaine before wound closure.
0.25% Bupivacaine
Periarticular injection with 20 ml of 0.25% bupivacaine before wound closure.
0.9% normal saline
Periarticular injection with 20 ml of 0.9% normal saline before wound closure.
0.9% normal saline
Periarticular injection with 20 ml of 0.9% normal saline before wound closure.
Interventions
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0.25% Bupivacaine
Periarticular injection with 20 ml of 0.25% bupivacaine before wound closure.
0.9% normal saline
Periarticular injection with 20 ml of 0.9% normal saline before wound closure.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* BMI between 20-35
* having a full understanding of the question in this trial
Exclusion Criteria
* blood creatinine more than 1.5 mg/dl or creatinine clearance less than 60 mL/min
* abnormal liver function
* previous surgery on the knee undergoing total knee replacement
* patient could not receive spinal anesthesia
50 Years
80 Years
ALL
No
Sponsors
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Siriraj Hospital
OTHER
Mahidol University
OTHER
Responsible Party
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Siriraj Hospital, Mahidol University
Principal Investigators
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Keerati Chareancholvanich, MD
Role: PRINCIPAL_INVESTIGATOR
Siriraj Hospital
Locations
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Siriraj Hospital
Bangkoknoi, Bangkok, Thailand
Countries
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References
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Mehrotra C, Remington PL, Naimi TS, Washington W, Miller R. Trends in total knee replacement surgeries and implications for public health, 1990-2000. Public Health Rep. 2005 May-Jun;120(3):278-82. doi: 10.1177/003335490512000310.
Akyol O, Karayurt O, Salmond S. Experiences of pain and satisfaction with pain management in patients undergoing total knee replacement. Orthop Nurs. 2009 Mar-Apr;28(2):79-85. doi: 10.1097/NOR.0b013e3181945f62.
Singelyn FJ, Deyaert M, Joris D, Pendeville E, Gouverneur JM. Effects of intravenous patient-controlled analgesia with morphine, continuous epidural analgesia, and continuous three-in-one block on postoperative pain and knee rehabilitation after unilateral total knee arthroplasty. Anesth Analg. 1998 Jul;87(1):88-92. doi: 10.1097/00000539-199807000-00019.
Toftdahl K, Nikolajsen L, Haraldsted V, Madsen F, Tonnesen EK, Soballe K. Comparison of peri- and intraarticular analgesia with femoral nerve block after total knee arthroplasty: a randomized clinical trial. Acta Orthop. 2007 Apr;78(2):172-9. doi: 10.1080/17453670710013645.
Vendittoli PA, Makinen P, Drolet P, Lavigne M, Fallaha M, Guertin MC, Varin F. A multimodal analgesia protocol for total knee arthroplasty. A randomized, controlled study. J Bone Joint Surg Am. 2006 Feb;88(2):282-9. doi: 10.2106/JBJS.E.00173.
Parvataneni HK, Shah VP, Howard H, Cole N, Ranawat AS, Ranawat CS. Controlling pain after total hip and knee arthroplasty using a multimodal protocol with local periarticular injections: a prospective randomized study. J Arthroplasty. 2007 Sep;22(6 Suppl 2):33-8. doi: 10.1016/j.arth.2007.03.034. Epub 2007 Jul 26.
Busch CA, Shore BJ, Bhandari R, Ganapathy S, MacDonald SJ, Bourne RB, Rorabeck CH, McCalden RW. Efficacy of periarticular multimodal drug injection in total knee arthroplasty. A randomized trial. J Bone Joint Surg Am. 2006 May;88(5):959-63. doi: 10.2106/JBJS.E.00344.
Related Links
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Total knee replacement
Bupivacaine information
Other Identifiers
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516/2552(EC3)
Identifier Type: -
Identifier Source: org_study_id
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