Evaluation of Toujeo Insulin in Type 2 Diabetes Patients Inadequately Control With Their Basal Insulin Treatment

NCT ID: NCT02967237

Last Updated: 2022-04-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

136 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-01-04

Study Completion Date

2017-07-24

Brief Summary

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Primary Objective:

The primary objective is to describe the effect of insulin glargine (U300) in type 2 diabetes mellitus (T2DM) patients uncontrolled with their current basal insulin therapy and eligible for basal switching, according to the Physician decision, on glycated hemoglobin (HbA1c) improvement.

Secondary Objectives:

* Evolution of fasting plasma glucose
* Evolution of insulin dose and body weight
* Hypoglycemia incidence
* Safety
* Patients satisfaction when they change their insulin for HOE901-U300

Detailed Description

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The total study duration per patient is approximately 28 weeks.

Conditions

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Diabetes Mellitus, Type 2

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Insulin glargine (U300)

Type 2 diabetes mellitus patients uncontrolled with their current basal insulin therapy switched according to the physician decision, to insulin glargine (U300) administered subcutaneously and once daily using a pre-filled pen

Group Type EXPERIMENTAL

insulin glargine (U300)

Intervention Type DRUG

Pharmaceutical form: solution Route of administration: subcutaneous

Interventions

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insulin glargine (U300)

Pharmaceutical form: solution Route of administration: subcutaneous

Intervention Type DRUG

Other Intervention Names

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HOE901; Toujeo

Eligibility Criteria

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Inclusion Criteria

* Type 2 diabetic adult patients treated with basal insulin, with or without oral anti-diabetic agents, with or without glucagon-like peptide-1 (GLP-1) receptor agonist
* HbA1c \> 7.5%

Exclusion Criteria

* Patients with high dose of insulin (\>1.2 U/kg)
* Use of prandial insulin
* Change of dose of antidiabetic drugs within the last 8 weeks
* Use of systemic glucocorticoids during at least 2 weeks in the last 12 weeks

The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sanofi

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Clinical Sciences & Operations

Role: STUDY_DIRECTOR

Sanofi

Locations

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Investigational Site Number 250017

Alençon, , France

Site Status

Investigational Site Number 250073

Alès, , France

Site Status

Investigational Site Number 250047

Amiens, , France

Site Status

Investigational Site Number 250028

Amilly, , France

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Investigational Site Number 250062

Bagnols-sur-Cèze, , France

Site Status

Investigational Site Number 250093

Bar-le-Duc, , France

Site Status

Investigational Site Number 250020

Besançon, , France

Site Status

Investigational Site Number 250081

Béthune, , France

Site Status

Investigational Site Number 250034

Bondy, , France

Site Status

Investigational Site Number 250022

Brest, , France

Site Status

Investigational Site Number 250070

Brest, , France

Site Status

Investigational Site Number 250060

Cahors, , France

Site Status

Investigational Site Number 250096

Cannes, , France

Site Status

Investigational Site Number 250072

Chambéry, , France

Site Status

Investigational Site Number 250037

Châlons-en-Champagne, , France

Site Status

Investigational Site Number 250018

Cholet, , France

Site Status

Investigational Site Number 250068

Clermont-Ferrand, , France

Site Status

Investigational Site Number 250098

Cognac, , France

Site Status

Investigational Site Number 250048

Colmar, , France

Site Status

Investigational Site Number 250088

Contamines Sur Arve, , France

Site Status

Investigational Site Number 250054

Coudray, , France

Site Status

Investigational Site Number 250063

Dijon, , France

Site Status

Investigational Site Number 250013

Eaubonne, , France

Site Status

Investigational Site Number 250095

Étampes, , France

Site Status

Investigational Site Number 250104

Grenoble, , France

Site Status

Investigational Site Number 250004

La Roche-sur-Yon, , France

Site Status

Investigational Site Number 250002

La Rochelle, , France

Site Status

Investigational Site Number 250019

La Seyne-sur-Mer, , France

Site Status

Investigational Site Number 250030

Lamagistère, , France

Site Status

Investigational Site Number 250103

Le Chesnay, , France

Site Status

Investigational Site Number 250053

Le Creusot, , France

Site Status

Investigational Site Number 250044

Le Mans, , France

Site Status

Investigational Site Number 250056

Lens, , France

Site Status

Investigational Site Number 250051

Lourdes, , France

Site Status

Investigational Site Number 250071

Mantes-la-Jolie, , France

Site Status

Investigational Site Number 250092

Marseille, , France

Site Status

Investigational Site Number 250064

Marseille, , France

Site Status

Investigational Site Number 250089

Maubeuge, , France

Site Status

Investigational Site Number 250083

Mérignac, , France

Site Status

Investigational Site Number 250035

Montpellier, , France

Site Status

Investigational Site Number 250061

Montpellier, , France

Site Status

Investigational Site Number 250010

Montpellier, , France

Site Status

Investigational Site Number 250008

Montpellier, , France

Site Status

Investigational Site Number 250032

Mulhouse, , France

Site Status

Investigational Site Number 250043

Nancy, , France

Site Status

Investigational Site Number 250005

Narbonne, , France

Site Status

Investigational Site Number 250069

Nevers, , France

Site Status

Investigational Site Number 250052

Nîmes, , France

Site Status

Investigational Site Number 250059

Noisy-le-Grand, , France

Site Status

Investigational Site Number 250058

Orléans, , France

Site Status

Investigational Site Number 250031

Paris, , France

Site Status

Investigational Site Number 250105

Paris, , France

Site Status

Investigational Site Number 250086

Paris, , France

Site Status

Investigational Site Number 250026

Paris, , France

Site Status

Investigational Site Number 250101

Pessac, , France

Site Status

Investigational Site Number 250084

Périgueux, , France

Site Status

Investigational Site Number 250107

Pointe à Pitre, , France

Site Status

Investigational Site Number 250067

Pontoise, , France

Site Status

Investigational Site Number 250078

Pringy, , France

Site Status

Investigational Site Number 250042

Reims, , France

Site Status

Investigational Site Number 250012

Roubaix, , France

Site Status

Investigational Site Number 250055

Roubaix, , France

Site Status

Investigational Site Number 250102

Saint-Brieuc, , France

Site Status

Investigational Site Number 250065

Saint-Denis, , France

Site Status

Investigational Site Number 250029

Saint-Mandé, , France

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Investigational Site Number 250108

Saint-Pierre, , France

Site Status

Investigational Site Number 250087

Seclin, , France

Site Status

Investigational Site Number 250090

Sète, , France

Site Status

Investigational Site Number 250006

Strasbourg, , France

Site Status

Investigational Site Number 250024

Strasbourg, , France

Site Status

Investigational Site Number 250033

Suresnes, , France

Site Status

Investigational Site Number 250057

Tarbes, , France

Site Status

Investigational Site Number 250001

Toulouse, , France

Site Status

Investigational Site Number 250076

Toulouse, , France

Site Status

Investigational Site Number 250082

Toulouse, , France

Site Status

Investigational Site Number 250050

Toulouse, , France

Site Status

Investigational Site Number 250027

Tours, , France

Site Status

Investigational Site Number 250075

Tours, , France

Site Status

Investigational Site Number 250041

Valenciennes, , France

Site Status

Investigational Site Number 250021

Vandœuvre-lès-Nancy, , France

Site Status

Investigational Site Number 250023

Vénissieux, , France

Site Status

Investigational Site Number 250039

Vichy, , France

Site Status

Investigational Site Number 250046

Vichy, , France

Site Status

Investigational Site Number 250100

Villeneuve-sur-Lot, , France

Site Status

Investigational Site Number 250007

Warloy-Baillon, , France

Site Status

Countries

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France

Other Identifiers

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2015-002416-33

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

U1111-1176-6203

Identifier Type: OTHER

Identifier Source: secondary_id

GLARGL07667

Identifier Type: -

Identifier Source: org_study_id

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