Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
5 participants
OBSERVATIONAL
2017-01-25
2021-10-28
Brief Summary
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Detailed Description
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The tumor tissue samples will be studied to look at certain proteins and enzymes, including enzymes called kinomes, that may be important in determining response and resistance to the treatment that participants will receive as a part of their cancer care.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Epithelial ovarian cancer
* Whole blood sample collection
* Up to 3 fresh tumor tissue core biopsies
* Tumor tissue sample taken from tumor tissue already removed from surgery (if surgery is planned)
Blood Draw
CA125 and ctDNA
Tumor Tissue Biopsy
Only collected at time of surgery if patient undergoes surgical debulking
Interventions
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Blood Draw
CA125 and ctDNA
Tumor Tissue Biopsy
Only collected at time of surgery if patient undergoes surgical debulking
Eligibility Criteria
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Inclusion Criteria
* Histological diagnosis of epithelial ovarian cancer
* Eastern Cooperative Oncology Group (ECOG) performance status ≤2.
* Life expectancy of greater than 3 months
* Diagnosis of epithelial ovarian cancer undergoing chemotherapy as part of standard care or a clinical trial OR receiving a targeted therapy with a targeted agent
* Must be agreeable to paired biopsies
* Must have disease amenable to paired biopsy.
* Ability to understand and the willingness to sign a written informed consent document.
Exclusion Criteria
* Need for anticoagulation that cannot be interrupted
18 Years
FEMALE
No
Sponsors
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University Health Network, Toronto
OTHER
Responsible Party
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Principal Investigators
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Amit Oza, M.D.
Role: PRINCIPAL_INVESTIGATOR
Princess Margaret Cancer Centre
Locations
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Princess Margaret Cancer Centre
Toronto, Ontario, Canada
Countries
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Other Identifiers
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KINOME
Identifier Type: -
Identifier Source: org_study_id
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