Genetic, Neurophysiological and Psychological Predictive Factors of Chronic Neuropathic Pain After Surgery for Breast Cancer

NCT ID: NCT02944721

Last Updated: 2017-11-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

2016-11-30

Study Completion Date

2021-04-30

Brief Summary

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The aim of the study is to establish the genetic, neurophysiological and psychological phenotype of the patients presenting a persistent neuropathic pain after surgery of the breast cancer, by comparing the neuropathic painful patients with the not painful and with the not neuropathic painful . This will be realized on a transverse cohort ("Seintinelle"cohort) and confirmed on a forward-looking longitudinal cohort.

Detailed Description

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Conditions

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Breast Cancer

Keywords

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Neuropathic Pain

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Transversal study

Patients who had surgery for breast cancer for 2 years or less

Group Type OTHER

Genetical analyses

Intervention Type GENETIC

Chronic pain identification questionnaires

Intervention Type OTHER

Neurophysiological and psychophysical evaluations

Intervention Type OTHER

Quality of life questionnaires

Intervention Type OTHER

Longitudinal study

Patients that must be operated for a breast cancer

Group Type OTHER

Genetical analyses

Intervention Type GENETIC

Chronic pain identification questionnaires

Intervention Type OTHER

Neurophysiological and psychophysical evaluations

Intervention Type OTHER

Quality of life questionnaires

Intervention Type OTHER

Interventions

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Genetical analyses

Intervention Type GENETIC

Chronic pain identification questionnaires

Intervention Type OTHER

Neurophysiological and psychophysical evaluations

Intervention Type OTHER

Quality of life questionnaires

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Women over 18 years
* Having given a written consent form
* Affiliated to the social security scheme
* French language (read, written and spoken)
* Accepting the principle of the study and able to respect the conditions of the study.


* Patients who can be followed during the total duration of the study ( 12 months) for the longitudinal arm of the forward-looking study
* Patients that must be operated for one of the two types of surgery: preservative surgery or mastectomy for breast cancer with ganglionic cleaning out
* Chemotherapy or radiotherapy before the surgery


\- patients operated for a conservative surgery or a mastectomy for breast cancer with ganglionic cleaning out during 2 years before the inclusion

Exclusion Criteria

* Other cancer or AIDS in evolution
* Bilateral Mastectomy
* Presence of chronic pain before the intervention for breast cancer,
* occupational accident, dispute or search for compensation
* Previous surgery on the same territory
* Peripheral neurological pathology or central (brain damage, multiple sclerosis) susceptible to interfere with the evaluation of the post-operative pain
* Heavy psychiatric histories: psychosis, severe depression having motivated a hospitalization, a suicide attempt
* Current major depressive episode at the time of the evaluation (cf. criterion diagnosis of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5))
* Abuse of drug or psychoactive substance (cf. definition of the DSM-5) during the last six months; cognitive disorders (MMSE 24/30) or psychological incompatible with the respect and/or the understanding of the protocol
* Patients participating in another protocol of biomedical research.

For longitudinal study:


* Previous surgery for a breast cancer
* Patients that must be operated for a surgery of the breast without ganglionic cleaning out

For transversal study:


* patients operated for a surgery of the breast without ganglionic cleaning out
* Patients operated for more than 2 years
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Hopital Foch

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Didier BOUHASSIRA, MD

Role: PRINCIPAL_INVESTIGATOR

AP-HP Hopital A. Paré

Locations

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Hopital Ambroise Paré

Boulogne, , France

Site Status

Centre René Huguenin

Saint-Cloud, , France

Site Status

Countries

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France

Other Identifiers

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2016-A00225-46

Identifier Type: OTHER

Identifier Source: secondary_id

2016/07

Identifier Type: -

Identifier Source: org_study_id