Characterization and Epigenetics of Post-Partum Preeclampsia

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

TERMINATED

Total Enrollment

12 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-02-01

Study Completion Date

2022-03-09

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study will recruit women with post partum pre-eclampsia and match them to controls without postpartum pre-eclampsia to identify an epigenetic signature that is specific to women with post partum pre-eclampsia to help characterize the underlying pathophysiology of post partum pre-eclampsia.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Epigenomic Dysregulation in Preeclampsia-Associated Chronic Hypertension

NCT01682304

Preeclampsia Hypertension Pregnancy Induced Hypertension

COMPLETED

Gene Expression In Pregnancies Complicated by Preeclampsia

NCT00919360

Preeclampsia

TERMINATED

Predicting Late-onset Preeclampsia at 10-14 Weeks of Pregnancy

NCT04075708

Preeclampsia

COMPLETED

Preeclampsia and Circulating Biomarkers

NCT02136667

Postpartum CVD Risk in Women With Previous Preeclampsia.

UNKNOWN

Prospective Study in Pregnant Women With Hypercoagulopathy

NCT00215969

Pre-Eclampsia Eclampsia

UNKNOWN

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Preeclampsia (PEC) is a heterogeneous disease that complicates 5-8% of pregnancies. Approximately 10% of PEC patients will present with post-partum PEC without having developed the syndrome during the pregnancy (PP-PEC). Management of post-partum preeclampsia (PP-PEC) is challenging because many women do not seek care until neurologic symptoms result from severe-range elevated blood pressure. The pathogenesis and clinical characteristics of PP-PEC are understudied and poorly understood. Identifying clinical risk factors and biomarkers of PP-PEC would help to identify women at risk.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Post Partum Pre-eclampsia

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

post partum pre-eclampsia

women with normal deliveries followed by post partum pre-eclampsia within 1 month of delivery.

no intervention

Intervention Type OTHER

database and epigenetic study

controls

women with normal deliveries and normal post part courses who match the post partum pre-eclampsia women in age, BMI, smoking status, gestational age and race/ethnicity.

no intervention

Intervention Type OTHER

database and epigenetic study

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

no intervention

database and epigenetic study

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Post partum pre-eclampsia

Matching based on:

* maternal age (years +/-3)
* BMI (+/-5 points)
* Ethnicity
* Mode of delivery
* Gestational age at delivery (+/7 days)
* Smoking status