Effects of Exercise Training on Cognitive Function and Neurotrophic Factors in Overweight Adults

NCT ID: NCT02915913

Last Updated: 2018-10-11

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 60 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2016-09-30
• Study Completion Date: 2016-12-31

Brief Summary

The BrainFit Study aims to examine acute effects of High Intensity Interval- vs Resistance or Combined program has benefits on Cognitive Function as well as on secretion and regulation of neurotrophic factors or neurotrophins in a cohort of sedentary, overweight adults (aged 18-30 years) from Bogota, Colombia.

Conditions

Cognitive Function; Motor Activity; Obesity

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: FACTORIAL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: SINGLE

Study Groups

High Intensity Interval

One session for 30-60 minutes of high intensity aerobic exercise

Group Type: EXPERIMENTAL

Experimental: High Intensity Interval

Intervention Type: BEHAVIORAL

Walking on a treadmill 4min at 80-90% peak heart rate and recovery 4 min at 65% peak heart rate until expenditure of 500 kcal

Resistance training

One session for 30-60 minutes of resistance exercise

Group Type: EXPERIMENTAL

Resistance training

Intervention Type: BEHAVIORAL

Completing a resistance circuit (including upper and lower muscle groups) as many times as needed according to subject weight until expenditure of 500 kcal

Plus: High Intensity Interval + Resistance Training

One session for 30-60 minutes of high intensity aerobic exercise and resistance exercise

Group Type: EXPERIMENTAL

Plus: High Intensity Interval + Resistance Training

Intervention Type: BEHAVIORAL

Walking on a treadmill as intervention 1 until 50% the energy expenditure prescribed is reached, then completing a resistance circuit until 100% energy expenditure is reached

Non-exercise

Non-exercise

Group Type: PLACEBO_COMPARATOR

Non-exercise

Intervention Type: OTHER

This group will receive the usual clinical care according to the consensus recommendations of the national goals for cardiovascular health promotion and disease reduction of the American Heart Association and Colombian guidelines COLDEPORTES.

Interventions

Experimental: High Intensity Interval

Walking on a treadmill 4min at 80-90% peak heart rate and recovery 4 min at 65% peak heart rate until expenditure of 500 kcal

Intervention Type: BEHAVIORAL

Resistance training

Completing a resistance circuit (including upper and lower muscle groups) as many times as needed according to subject weight until expenditure of 500 kcal

Intervention Type: BEHAVIORAL

Plus: High Intensity Interval + Resistance Training

Walking on a treadmill as intervention 1 until 50% the energy expenditure prescribed is reached, then completing a resistance circuit until 100% energy expenditure is reached

Intervention Type: BEHAVIORAL

Non-exercise

This group will receive the usual clinical care according to the consensus recommendations of the national goals for cardiovascular health promotion and disease reduction of the American Heart Association and Colombian guidelines COLDEPORTES.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Written informed consent.
• Interested in improving health and fitness.
• Central obesity: waist circumference ≥90cm
• Body mass index ≥ 26 kg/m(2)

Exclusion Criteria

• Systemic infections.
• Weight loss or gain of >10% of body weight in the past 6 months for any reason.
• Currently taking medication that suppresses or stimulates appetite.
• Uncontrolled hypertension: systolic blood pressure 160 mm Hg or diastolic blood pressure 95 mm Hg on treatment.
• Gastrointestinal disease, including self-reported chronic hepatitis or cirrhosis, any episode of alcoholic hepatitis or alcoholic pancreatitis within past year, inflammatory bowel disease requiring treatment in the past year, recent or significant abdominal surgery (e.g., gastrectomy).
• Asthma.
• Diagnosed diabetes (type 1 or 2), fasting impaired glucose tolerance (blood glucose 118 mg/dL), or use of any anti-diabetic medications.
• Currently taking antidepressant, steroid, or thyroid medication, unless dosage is stable (no change for 6 months).
• Any active use of illegal or illicit drugs.
• Current exerciser (>30 min organized exercise per week).
• Indication of unsuitability of current health for exercise protocol (PARQ).

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 30 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

Universidad del Rosario

OTHER

Sponsor Role: collaborator

Universidad Nacional de Colombia

OTHER

Sponsor Role: collaborator

Universidad Santo Tomas

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Robinson Ramírez-Vélez, Ph.D

Role: STUDY_DIRECTOR

Universidad del Rosario

Locations

Robinson Ramírez-Vélez

Bogota, Cundinamarca, Colombia

Countries

Colombia

References

Dominguez-Sanchez MA, Bustos-Cruz RH, Velasco-Orjuela GP, Quintero AP, Tordecilla-Sanders A, Correa-Bautista JE, Triana-Reina HR, Garcia-Hermoso A, Gonzalez-Ruiz K, Pena-Guzman CA, Hernandez E, Pena-Ibagon JC, Tellez-T LA, Izquierdo M, Ramirez-Velez R. Acute Effects of High Intensity, Resistance, or Combined Protocol on the Increase of Level of Neurotrophic Factors in Physically Inactive Overweight Adults: The BrainFit Study. Front Physiol. 2018 Jun 27;9:741. doi: 10.3389/fphys.2018.00741. eCollection 2018.

Reference Type: DERIVED

PMID: 29997519 (View on PubMed)

Other Identifiers

2016-09-22

Identifier Type: -

Identifier Source: org_study_id