Exploratory Trial of TAS-303 in Female Patients With Stress Urinary Incontinence

NCT ID: NCT02906683

Last Updated: 2024-09-26

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

337 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-10-20

Study Completion Date

2018-04-30

Brief Summary

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The purpose of this study is to evaluate the efficacy and safety of TAS-303 in female patients with stress urinary incontinence.

Detailed Description

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The main purpose of this study is to assess the efficacy of TAS-303 for 8 weeks in female patients with stress urinary incontinence (SUI) compared with placebo as measured by the percent change in incontinence episode frequency (IEF) from baseline.

Conditions

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Stress Urinary Incontinence

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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TAS-303 3mg

Group Type EXPERIMENTAL

TAS-303

Intervention Type DRUG

Oral administration for 8 weeks, once daily.

TAS-303 6mg

Group Type EXPERIMENTAL

TAS-303

Intervention Type DRUG

Oral administration for 8 weeks, once daily.

Placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Oral administration for 8 weeks, once daily.

Interventions

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TAS-303

Oral administration for 8 weeks, once daily.

Intervention Type DRUG

Placebo

Oral administration for 8 weeks, once daily.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patient has symptoms of Stress Urinary Incontinence (SUI) for at least 12 weeks prior to study entry
* Patient has at least 1 incontinence episodes per day, and urinary diurnal frequency of 10 or less per day and nocturia of 2 or less per day.
* Patient is positive in 1-hour pad weight test

Exclusion Criteria

* Patient has predominant or primary urge incontinence according to investigator judgment
* Patient had a prior surgical SUI treatment
* Patient is diagnosed stageII or more of Pelvic Organ Prolapse
* Patient has symptoms of Urinary tract infection (UTI)
* Patient is positive pregnancy test
* Patient has on physical examination, neurological and/or vaginal examination results which, in the opinion of the investigator, should exclude the subject.
Minimum Eligible Age

20 Years

Maximum Eligible Age

79 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Taiho Pharmaceutical Co., Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Taiho Pharmaceutical Co., Ltd

Role: STUDY_DIRECTOR

Taiho Pharmaceutical Co., Ltd.

Locations

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Taiho Pharmaceutical Co., Ltd selected site

Osaka, , Japan

Site Status

Countries

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Japan

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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10060050

Identifier Type: -

Identifier Source: org_study_id

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