The Effect of When Medication is Taken on Nutritional Status in Hospitalized Patients Older Than 65 Years

NCT ID: NCT02894827

Last Updated: 2016-09-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Brief Summary

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Polypathology in elderly subjects requires polypharmacy but even though the efficacy of a medication and digestive tolerance are ensured, the medication can be taken a long time from meals to reduce its side-effects. Despite numerous studies that have investigated links between medication and malnutrition, none have assessed the influence of the time the drug is taken on the evolution of the nutritional status of elderly hospitalized persons. So as to identify the best nutritional criterion in hospitalized persons, a retrospective pilot study will be conducted in about thirty patients. Their medication will be recorded and their nutritional status will be evaluated using the Geriatric Nutritional Risk Index (GNRI), albumin, prealbumin levels, weight and the Mini Nutritional Assessment (MNA) short form.

This preliminary study will allow us to choose the best nutritional criterion to compare the impact of two strategies for taking medication (post prandial versus pre-prandial) on improving the nutritional status of malnourished elderly hospitalized patients taking multiple drugs.

Detailed Description

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Conditions

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Nutritional Status

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

RETROSPECTIVE

Study Groups

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EMS

Blood sample

Intervention Type BIOLOGICAL

Flow cytometry

Intervention Type OTHER

western blot

Intervention Type OTHER

Control

Blood sample

Intervention Type BIOLOGICAL

Flow cytometry

Intervention Type OTHER

western blot

Intervention Type OTHER

Interventions

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Blood sample

Intervention Type BIOLOGICAL

Flow cytometry

Intervention Type OTHER

western blot

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* patients aged 65 years or more.
* patients with a stable or controlled acute disease hospitalized in a geriatric follow-up care unit.
* patients whose life expectancy is greater than 30 days.
* patients able to eat food normally.
* patients able to swallow their medication.
* patients with at least 3 drugs to be taken orally per day, not including oral nutritional supplements.

Exclusion Criteria

* patients at the end of life.
* patients whose drugs must be taken before meals like Non-steroid anti-inflammatory drugs (NSAIDs), glinides, oral antidiabetic agents (OAD).
* patients with parenteral and/or enteral nutrition in the period preceding admission to the geriatric unit.
* patients with indications for parental and/or enteral nutrition.
Minimum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Centre Hospitalier Universitaire Dijon

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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CHU Dijon Bourgogne

Dijon, , France

Site Status

Countries

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France

Other Identifiers

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VAN WYMELBEKE 2015

Identifier Type: -

Identifier Source: org_study_id

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