Plasma Level of Mitochondrial DNA in Patients With ARDS and Its Clinical Significance

NCT ID: NCT02883231

Last Updated: 2016-08-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-04-30

Study Completion Date

2017-03-31

Brief Summary

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To observe the changes of plasma mitochondrial DNA (mtDNA) levels in patients with ARDS, and to explore its clinical significance.

Detailed Description

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60 patients who diagnosed as ARDS were included in this study.Then keep blood samples from these patients in the first day、the third day and the sveventh day,detect the mitochotndrial DNA level in plasma by real-time quantitative PCR. Recored Severity of illness and survival status of every patient within 28 days.Objective to evaluate the correlation between the level of mitochondrial DNA in plasma and the prognosis of the patients.

Conditions

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Evaluate the Correlation Between the Level of Mitochondrial DNA in Plasma and the Prognosis of the Patients With ARDS.

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Interventions

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taking peripheral blood

taking peripheral blood of no more than 3ml

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Patients admitted to ICU diagnosed of ARDS (Berlin criteria),
2. Patients age between 18 years old and 80 years.

Exclusion Criteria

1. Pregnant women,
2. Patients with malignant tumor,
3. Immunosuppression or immunocompromised patients.
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Chun Pan

OTHER

Sponsor Role lead

Responsible Party

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Chun Pan

attending doctor

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Zhongda Hospital

Nanjing, Jiangsu, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Lili Huang, Dr

Role: CONTACT

13770840246

Haibo Qiu, Dr

Role: CONTACT

+862583262550

Facility Contacts

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Lili Huang, Dr

Role: primary

13770840246

References

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Peng F, Liang C, Chang W, Sun Q, Xie J, Qiu H, Yang Y. Prognostic Significance of Plasma Hepatocyte Growth Factor in Sepsis. J Intensive Care Med. 2022 Mar;37(3):352-358. doi: 10.1177/0885066621993423. Epub 2021 Feb 22.

Reference Type DERIVED
PMID: 33611982 (View on PubMed)

Other Identifiers

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ARDS mtDNA

Identifier Type: -

Identifier Source: org_study_id

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