Role of PTK-7 in Acute Myeloid Leukemias

NCT ID: NCT02860793

Last Updated: 2016-08-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-01-31

Brief Summary

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The pseudo tyrosine kinase receptor 7 (PTK7) is an orphan tyrosine kinase receptor assigned to the planar cell polarity pathway. PTK7 is expressed in normal myeloid progenitors and CD34(+) CD38(-) bone marrow cells in humans. It is also expressed in acute myeloid leukemia (AML) and is mostly assigned to granulocytic lineage differentiation. In AML, PTK7 seems to convey promigratory and antiapoptotic signals into the cell and represents an independent prognosis factor of survival in patients treated with induction chemotherapy. This study aims at:

* evaluating the impact of PTK7 expression on primary AML cells ex vivo
* evaluating the diagnostic and prognostic value of a soluble form of PTK7

Detailed Description

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Conditions

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Acute Myeloid Leukemia

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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AML patients at diagnosis

Group Type EXPERIMENTAL

Bone marrow aspiration

Intervention Type OTHER

Blood sampling

Intervention Type OTHER

Interventions

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Bone marrow aspiration

Intervention Type OTHER

Blood sampling

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Age\> 18 years
* AML at diagnosis, not previously treated
* Treatment by induction chemotherapy
* Signed informed consent
* Affiliation to the French social security system

Exclusion Criteria

* pregnant woman(or of childbearing potential) or breastfeeding woman
* emergency
* patients deprived of liberty or placed under the authority of a tutor
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Institut Paoli-Calmettes

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Norbert VEY, MD

Role: PRINCIPAL_INVESTIGATOR

Institut Paoli-Calmettes

Locations

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Institut Paoli Calmettes

Marseille, Bouches du Rhone, France

Site Status

Countries

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France

Other Identifiers

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LAM-PTK7-IPC 2013-011

Identifier Type: -

Identifier Source: org_study_id

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