Development of Ovarian Tissue Autograft in Order to Restore Ovarian Function

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-10-31

Study Completion Date

2024-12-31

Brief Summary

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Ovarian cryopreservation is one of the available option for preserving fertility prior to potentially sterilizing treatments. In the absence of other techniques such as in vitro folliculogenesis or injection of isolated ovarian follicles, this tissue can only be re-used by autograft. In France, the first live birth after orthotopic ovarian transplantation, was obtained by Roux et al. in 2009. This clinical trial aims to collect data on the efficiency of the graft in terms of restoration of ovarian function and live births. It will also allow us to carry out the patient follow-up after ovarian tissue cryopreservation and after autograft when achieved. In cases of neoplastic malignancies, minimal residual disease detection will be performed on ovarian tissue, to avoid any risk of cancer re-seeding.

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Detailed Description

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Conditions

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Ovarian Function Insufficiency

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Ovarian tissue cryopreservation

Group Type OTHER

Autograft of cryopreserved ovarian tissue

Intervention Type PROCEDURE

Orthotopic transplantation

Interventions

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Autograft of cryopreserved ovarian tissue

Orthotopic transplantation

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients who underwent Ovarian tissue cryopreservation
* Premature ovarian failure
* Patients cured of their primary disease
* Women between 18 and 43 years of age
* Patients who have already benefited from ovarian tissue autograft