Tissue Adhesive vs. Sterile Strips After Cesarean Delivery

NCT ID: NCT02838017

Last Updated: 2019-08-14

Study Results

Results available

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Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

504 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-11-30

Study Completion Date

2018-06-30

Brief Summary

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The goal of this project is to identify a strategy to reduce wound complications in women who undergo cesarean delivery by Pfannenstiel skin incision. Currently, many Pfannenstiel skin incisions are closed by subcuticular sutures followed by either placement of sterile strips or tissue A\\adhesive. Either sterile strips or tissue adhesive can be placed over the wound as a covering but it is unclear which may reduce wound complication rates. The hypothesis of this study is that tissue adhesive will result in a reduction in wound complication rates when compared to sterile strips. Previously published studies in non-obstetric populations have identified tissue adhesive as a potential intervention to reduce wound complications. The eligible population for this study will include women at NorthShore University HealthSystem Evanston Hospital and University of Chicago Hospital who will undergo primary or repeat cesarean delivery via Pfannenstiel skin incision. Women in the study will be randomized to receive either sterile strips or tissue adhesive. The primary outcome to be evaluated will be a composite of wound complication which will include drainage, cellulitis, hematoma, seroma and/or wound separation (partial or complete). Secondary endpoints to be investigated include cosmetic outcome, patient satisfaction, cost comparison, and difference in operative times.

Detailed Description

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Conditions

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Wound Complication Complications; Cesarean Section

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Tissue Adhesive

Tissue Adhesive will be placed over subcuticular suture closure.

Group Type EXPERIMENTAL

Tissue Adhesive

Intervention Type DEVICE

Steri-Strips

Sterile strips will be placed over subcuticular suture closure.

Group Type ACTIVE_COMPARATOR

Sterile strips

Intervention Type DEVICE

Interventions

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Tissue Adhesive

Intervention Type DEVICE

Sterile strips

Intervention Type DEVICE

Other Intervention Names

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Dermabond Dermaflex 2-octyl cyanoacrylate Steri-Strips

Eligibility Criteria

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Inclusion Criteria

* Women undergoing Pfannenstiel Cesarean delivery

Exclusion Criteria

* Inability to provide informed consent in English
* Planned use of staples for skin closure
* Unavailability of research personnel to accomplish consent and randomization at the time of cesarean
Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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University of Chicago

OTHER

Sponsor Role collaborator

Endeavor Health

OTHER

Sponsor Role lead

Responsible Party

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Beth Plunkett

Clinical Associate Professor, Maternal & Fetal Medicine, Obstetrics & Gynecology

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Beth Plunkett, MD

Role: PRINCIPAL_INVESTIGATOR

Endeavor Health

Lena Braginsky, MD

Role: STUDY_DIRECTOR

Endeavor Health

Locations

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University of Chicago

Chicago, Illinois, United States

Site Status

NorthShore Evanston Hospital

Evanston, Illinois, United States

Site Status

NorthShore Highland Park Hospital

Highland Park, Illinois, United States

Site Status

Countries

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United States

References

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Souza EC, Fitaroni RB, Januzelli DM, Macruz HM, Camacho JC, Souza MR. Use of 2-octyl cyanoacrylate for skin closure of sternal incisions in cardiac surgery: observations of microbial barrier effects. Curr Med Res Opin. 2008 Jan;24(1):151-5. doi: 10.1185/030079908x253807.

Reference Type BACKGROUND
PMID: 18034920 (View on PubMed)

Mackeen AD, Packard RE, Ota E, Berghella V, Baxter JK. Timing of intravenous prophylactic antibiotics for preventing postpartum infectious morbidity in women undergoing cesarean delivery. Cochrane Database Syst Rev. 2014 Dec 5;2014(12):CD009516. doi: 10.1002/14651858.CD009516.pub2.

Reference Type BACKGROUND
PMID: 25479008 (View on PubMed)

Noorani A, Rabey N, Walsh SR, Davies RJ. Systematic review and meta-analysis of preoperative antisepsis with chlorhexidine versus povidone-iodine in clean-contaminated surgery. Br J Surg. 2010 Nov;97(11):1614-20. doi: 10.1002/bjs.7214.

Reference Type BACKGROUND
PMID: 20878942 (View on PubMed)

Stamilio DM, Scifres CM. Extreme obesity and postcesarean maternal complications. Obstet Gynecol. 2014 Aug;124(2 Pt 1):227-232. doi: 10.1097/AOG.0000000000000384.

Reference Type BACKGROUND
PMID: 25004353 (View on PubMed)

Tipton AM, Cohen SA, Chelmow D. Wound infection in the obese pregnant woman. Semin Perinatol. 2011 Dec;35(6):345-9. doi: 10.1053/j.semperi.2011.05.020.

Reference Type BACKGROUND
PMID: 22108085 (View on PubMed)

Buresch AM, Van Arsdale A, Ferzli M, Sahasrabudhe N, Sun M, Bernstein J, Bernstein PS, Ngai IM, Garry DJ. Comparison of Subcuticular Suture Type for Skin Closure After Cesarean Delivery: A Randomized Controlled Trial. Obstet Gynecol. 2017 Sep;130(3):521-526. doi: 10.1097/AOG.0000000000002200.

Reference Type BACKGROUND
PMID: 28796687 (View on PubMed)

Daykan Y, Sharon-Weiner M, Pasternak Y, Tzadikevitch-Geffen K, Markovitch O, Sukenik-Halevy R, Biron-Shental T. Skin closure at cesarean delivery, glue vs subcuticular sutures: a randomized controlled trial. Am J Obstet Gynecol. 2017 Apr;216(4):406.e1-406.e5. doi: 10.1016/j.ajog.2017.01.009. Epub 2017 Jan 30.

Reference Type BACKGROUND
PMID: 28153666 (View on PubMed)

Braginsky L, Javellana M, Cleveland E, Elue R, Wang C, Boyle D, Plunkett BA. Tissue Adhesive Compared With Sterile Strips After Cesarean Delivery: A Randomized Controlled Trial. Obstet Gynecol. 2019 Aug;134(2):295-301. doi: 10.1097/AOG.0000000000003367.

Reference Type DERIVED
PMID: 31306319 (View on PubMed)

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

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EH16-095

Identifier Type: -

Identifier Source: org_study_id

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