Tissue Lesions in Exercise Related Ischemia

NCT ID: NCT02834351

Last Updated: 2016-12-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

36 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-07-31

Study Completion Date

2016-11-30

Brief Summary

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The purpose of this study is to evaluate the effect of muscle ischemia during claudication on mitochondrial function.

Comparison to patients with arterial disease but absence of lower limb claudication (Cardiac group) feasibility study.

Detailed Description

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Assess the feasibility of the study of micro-vascular function and mitochondrial on muscle sample (sartorius) in a group of arterial disease and non arteriopathy group.

Analysis of the activity of mitochondrial chain Immunochemistry of tissue markers

Conditions

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Ischemia Peripheral Artery Disease

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Investigators

Study Groups

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Peripheral artery diseased group

pad Patients referred for femoro popliteal bypass Muscle biopsy during surgery

Group Type ACTIVE_COMPARATOR

Muscle Biopsy

Intervention Type OTHER

A distal and proximal biopsy of the sartorius muscles ( 0.5 cm3 each) will be performed during surgery for saphenous vein withdrawal (cardiac group) or arterial bypass (PAD group) The samples are then treated with neurovascular and mitochondrial biology laboratory.

the activity of the complex 1 is analyzed and compared between the 2 groups.

Cardiac group

Patients referred for saphenous withdrawal for coronary bypass Muscle biopsy during surgery

Group Type SHAM_COMPARATOR

Muscle Biopsy

Intervention Type OTHER

A distal and proximal biopsy of the sartorius muscles ( 0.5 cm3 each) will be performed during surgery for saphenous vein withdrawal (cardiac group) or arterial bypass (PAD group) The samples are then treated with neurovascular and mitochondrial biology laboratory.

the activity of the complex 1 is analyzed and compared between the 2 groups.

Interventions

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Muscle Biopsy

A distal and proximal biopsy of the sartorius muscles ( 0.5 cm3 each) will be performed during surgery for saphenous vein withdrawal (cardiac group) or arterial bypass (PAD group) The samples are then treated with neurovascular and mitochondrial biology laboratory.

the activity of the complex 1 is analyzed and compared between the 2 groups.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Intervention for femoropopliteal bypass (PAD group)
* Intervention for saphenous withdrawal for coronary bypass surgery (cardiac group)

Exclusion Criteria

* Participate in another biomedical research
* Pregnant woman
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Angers

OTHER_GOV

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Pierre ABRAHAM, PROFESSOR

Role: PRINCIPAL_INVESTIGATOR

UH ANGERS

Locations

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Uh Angers

Angers, , France

Site Status

Countries

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France

Other Identifiers

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2013-A00166-39

Identifier Type: -

Identifier Source: org_study_id