Changes in Measured Plasma Volume, Glycocalyx and Atrial Natriuretic Peptide During Anaesthesia
NCT ID: NCT02832596
Last Updated: 2020-04-30
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
24 participants
INTERVENTIONAL
2016-10-31
2019-08-20
Brief Summary
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Detailed Description
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Changes in vascular resistance and cardiac output will be measured with thermodilution and changes in plasma volume will be measured with 125I-HSA.
Endothelial cell function will be evaluated by measuring leakage of 125I-HSA and the plasma concentration of endothelial cell markers. Hormonal effects will be evaluated by measuring the plasma concentration of atrial natriuretic peptide (ANP). Shedding of glycocalyx will be evaluated by measuring heparan sulphate. The level of fibrinogen and platelet function will be evaluated by thromboelastography/multiplate.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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Control
Ordinary anesthesia, mean arterial pressure allowed to decrease to 60 mmHg. If it is lower the patients will receive a norepinephrine infusion in order to raise the mean arterial pressure to 60 mmHg.
No interventions assigned to this group
Maintained blood pressure
Ordinary anaesthesia and maintained preanesthetic blood pressure by norepinephrine infusion
Norepinephrine
Ordinary anaesthesia and maintained preanesthetic blood pressure by norepinephrine infusion
Maintained blood pressure
Norepinephrine therapy to maintain preanesthesia blood pressure
Interventions
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Norepinephrine
Ordinary anaesthesia and maintained preanesthetic blood pressure by norepinephrine infusion
Maintained blood pressure
Norepinephrine therapy to maintain preanesthesia blood pressure
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Untreated hypertension
* A reduced left ventricular systolic ejection fraction of 45% or less
* Diabetes mellitus
* Former stroke and/or a known carotid artery stenosis
40 Years
90 Years
ALL
No
Sponsors
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Sahlgrenska University Hospital
OTHER
Responsible Party
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Tor Damén
Doctor
Principal Investigators
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Andreas Nygren, MD PHD
Role: PRINCIPAL_INVESTIGATOR
Sahlgrenska University Hospital
Locations
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Sahlgrenska University Hospital
Gothenburg, , Sweden
Countries
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Other Identifiers
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Plasmavolume TDamen
Identifier Type: -
Identifier Source: org_study_id
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