Role of the Interaction Between Advanced Glycation End Products and Their Receptor RAGE in the Development and the Progression of the Uremic Vasculopathy of Hemodialyzed Patients

NCT ID: NCT02818465

Last Updated: 2026-01-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-03-30

Study Completion Date

2017-11-16

Brief Summary

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Chronic kidney disease (CKD) is associated with an extensive vasculopathy and high cardiovascular mortality as well as an accumulation of uremic toxins. Among the latest, advanced glycation end-products (AGEs) interact with RAGE. Investigators aimed to analyze the role of RAGE in the calcification process of hemodialyzed patients, in a correlative and prospective study. Vascular calcifications will be assessed by Xray and tomodentimetry while accumulation of AGEs will be measured in the serum and in the skin (non invasive). Additionally factors influencing RAGE activation such as genetic polymorphism and level of soluble forms of RAGE will be measured and analyzed.

Detailed Description

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Conditions

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Hemodialyzed Patients

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Patients

Group Type EXPERIMENTAL

Vascular calcifications by Xray

Intervention Type OTHER

Vascular calcifications by tomodentimetry

Intervention Type OTHER

Blood sample withdrawn

Intervention Type BIOLOGICAL

Interventions

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Vascular calcifications by Xray

Intervention Type OTHER

Vascular calcifications by tomodentimetry

Intervention Type OTHER

Blood sample withdrawn

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Renal impairment
* Hemodialysis for more than 3 months
* Have agreed to participate in research
* Affiliated to a social security scheme
* major

Exclusion Criteria

* Diabetes , for diabetes induces accelerated formation of advanced glycation end products , which could then be a confounding factor in our study.
* Protected by law .
* minors
* pregnant women
* Matt or pigmented skin because the skin hyperpigmentation interfere with reading the skin fluorescence giving falsely elevated values .
* Having an aneurysm of the abdominal aorta known
* Suffering from a progressive neoplastic disease
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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CHU de Reims

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Chu de Reims

Reims, , France

Site Status

Countries

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France

References

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Belmokhtar K, Ortillon J, Jaisson S, Massy ZA, Boulagnon Rombi C, Doue M, Maurice P, Fritz G, Gillery P, Schmidt AM, Rieu P, Toure F. Receptor for advanced glycation end products: a key molecule in the genesis of chronic kidney disease vascular calcification and a potential modulator of sodium phosphate co-transporter PIT-1 expression. Nephrol Dial Transplant. 2019 Dec 1;34(12):2018-2030. doi: 10.1093/ndt/gfz012.

Reference Type BACKGROUND
PMID: 30778553 (View on PubMed)

Other Identifiers

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PR14037

Identifier Type: -

Identifier Source: org_study_id

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