Motor Slowing and Its Lesion-related Correlates in Alzheimer's Disease
NCT ID: NCT02811653
Last Updated: 2023-03-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
155 participants
INTERVENTIONAL
2015-12-01
2023-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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Alzheimer disease
Alzheimer disease patients Brain MRI (Magnetic Resonance Imaging) Blood neuropsychological evaluation
Brain MRI
neuropsychological evaluation
Blood
control
Healthy age- and gender-matched volunteers will be recruited into the study from the general population.
Brain MRI (Magnetic Resonance Imaging) Blood neuropsychological evaluation
Brain MRI
neuropsychological evaluation
Blood
Interventions
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Brain MRI
neuropsychological evaluation
Blood
Eligibility Criteria
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Inclusion Criteria
* Age between 40 and 85
* French mother tongue
* Consulting at the Amiens Memory Resource and Research Centre (CMRR) for:
* MCI, according to Albert et al.'s criteria (Albert et al., 2011)
* Mild dementia (MMSE\>20) due to AD, according to McKhann's criteria (McKhann et al., 2011).
* Mild dementia due to LBD, according to McKeith et al.'s criteria (McKeith et al., 2005).
* Mild dementia due to FTLD, according to Rascovsky et al.'s criteria (Rascovsky et al., 2011).
* Social security coverage
* Healthy controls
* Healthy age and gender matched volunteers will be recruited into the study from the general population.
Exclusion Criteria
* A medical history with a potentially significant impact on cognition (non-corrected thyroid disorders or heart failure):
* NYHA stage IV dyspnoea.
* respiratory impairment requiring oxygen therapy.
* liver impairment.
* kidney failure, progressing neoplastic disease, or past or present alcohol abuse.
* Past or present neurological disorders other than those having prompted consultation in the Memory Clinic:
* stroke.
* meningitis or encephalitis.
* severe head injury.
* sensorimotor impairments (sensory, proprioceptive, cerebellar and visual impairments).
* epilepsy (requiring ongoing treatment),
* psychiatric disorders (other than treated depression).
* treatment with psychotropic medications (other than anxiolytics or antidepressant withdrawn or initiated in the previous month). Patients with parkinsonian syndrome were examined in the "on-drug" state.
* Impossibility to perform a neuropsychological evaluation or brain MRI.
* Withdrawal from the study at any time, if desired.
* Pregnancy
* Contra-indication to MRI:
* nerve stimulators
* cochlear implants
* ferromagnetic foreign bodies close to nervous structures in the eye or brain
* cerebral shunts
* dental appliances
* Legal guardianship or incarceration.
40 Years
85 Years
ALL
Yes
Sponsors
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Centre Hospitalier Universitaire, Amiens
OTHER
Responsible Party
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Principal Investigators
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Daniela ANDRIUTA, PhD
Role: PRINCIPAL_INVESTIGATOR
CHU Amiens
Locations
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CHU Amiens
Amiens, , France
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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PI2015_843_0003
Identifier Type: -
Identifier Source: org_study_id
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