Long Term Post Marketing Specified Drug Use Result Survey for Evolocumab in Japan

NCT ID: NCT02808403

Last Updated: 2024-11-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

6000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-06-24

Study Completion Date

2023-03-30

Brief Summary

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The purpose of this post-marketing survey is to obtain real-world information on the safety and effectiveness of evolocumab in Japan.

Detailed Description

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The objectives of study are to 1) determine the incidence of adverse events and adverse drug reactions among patients receiving evolocumab for up to 2 years, and 2) identify and describe patient characteristics (e.g. demographics, medical history) associated with the safety and effectiveness of evolocumab therapy for the patients with Familial Hypercholesterolemia (Heterozygous or Homozygous) and Hypercholesterolemia in Japan

Conditions

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Hypercholesterolemia Familial Hypercholesterolemia

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Evolocumab exposed

Patients for whom evolocumab is prescribed. Dosage, period (start/end date), frequency of injection (Every 2 weeks (Q2W), Every 4 weeks (Q4W)), drug withdrawal (Yes or No, date, reason) and injection site (upper arm, abdomen, thigh) of evolocumab will be collected.

No intervention

Intervention Type OTHER

No intervention; observation of routine medical care

Interventions

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No intervention

No intervention; observation of routine medical care

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients for whom evolocumab is prescribed at participating medical institutions in accordance with the approved Japan prescribing information (i.e., those with Familial Hypercholesterolemia (Heterozygous or Homozygous and Hypercholesterolemia who have high risk factors for cardiovascular event and do not respond sufficiently to HMGCoA reductase inhibitor (statin) for hypercholesterolemia).
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Amgen

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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MD

Role: STUDY_DIRECTOR

Amgen

Locations

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Research Site

Ichinomiya, Aichi-ken, Japan

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Ichinomiya, Aichi-ken, Japan

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Inuyama, Aichi-ken, Japan

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Kasugai, Aichi-ken, Japan

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Komaki, Aichi-ken, Japan

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Nagoya, Aichi-ken, Japan

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Nagoya, Aichi-ken, Japan

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Nagoya, Aichi-ken, Japan

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Nagoya, Aichi-ken, Japan

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Nagoya, Aichi-ken, Japan

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Nagoya, Aichi-ken, Japan

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Nagoya, Aichi-ken, Japan

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Tsushima, Aichi-ken, Japan

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Akita, Akita, Japan

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Yuzawa, Akita, Japan

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Asahi, Chiba, Japan

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Chiba, Chiba, Japan

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Chosei Gun, Chiba, Japan

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Ichihara, Chiba, Japan

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Ichikawa, Chiba, Japan

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Kisarazu, Chiba, Japan

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Matsudo, Chiba, Japan

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Matsuyama, Ehime, Japan

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Fukuoka, Fukuoka, Japan

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Fukuoka, Fukuoka, Japan

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Fukuoka, Fukuoka, Japan

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Itoshima, Fukuoka, Japan

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Kitakyushu, Fukuoka, Japan

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Kitakyushu, Fukuoka, Japan

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Omuta, Fukuoka, Japan

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Futaba Gun, Fukushima, Japan

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Iwaki, Fukushima, Japan

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Kōriyama, Fukushima, Japan

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Kani, Gifu, Japan

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Mino, Gifu, Japan

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Nagahama City, Gifu, Japan

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Fujioka, Gunma, Japan

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Kiryū, Gunma, Japan

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Takasaki, Gunma, Japan

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Fukuyama, Hiroshima, Japan

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Higashihiroshima, Hiroshima, Japan

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Hiroshima, Hiroshima, Japan

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Onomichi, Hiroshima, Japan

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Iwamizawa, Hokkaido, Japan

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Sapporo, Hokkaido, Japan

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Sapporo, Hokkaido, Japan

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Sapporo, Hokkaido, Japan

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Sapporo, Hokkaido, Japan

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Himeji, Hyogo Prefectural, Japan

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Kobe, Hyogo Prefectural, Japan

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Kobe, Hyogo Prefectural, Japan

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Sanda, Hyogo Prefectural, Japan

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Kobe, Hyōgo, Japan

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Kobe, Hyōgo, Japan

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Kobe, Hyōgo, Japan

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Kobe, Hyōgo, Japan

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Higashiibaraki Gun, Ibaraki, Japan

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Hitachi, Ibaraki, Japan

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Mito, Ibaraki, Japan

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Kahoku Gun, Ishikawa-ken, Japan

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Kanazawa, Ishikawa-ken, Japan

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Kanazawa, Ishikawa-ken, Japan

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Kanazawa, Ishikawa-ken, Japan

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Kanazawa, Ishikawa-ken, Japan

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Mukai-awagasaki, Ishikawa-ken, Japan

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Kitakami, Iwate, Japan

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Morioka, Iwate, Japan

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Kita Gun, Kagawa-ken, Japan

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Sakaidechō, Kagawa-ken, Japan

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Zentsujichó, Kagawa-ken, Japan

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Kagoshima, Kagoshima-ken, Japan

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Kagoshima, Kagoshima-ken, Japan

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Kanoya, Kagoshima-ken, Japan

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Fujisawa, Kanagawa, Japan

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Kawasaki, Kanagawa, Japan

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Kawasaki, Kanagawa, Japan

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Miura, Kanagawa, Japan

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Yokohama, Kanagawa, Japan

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Yokohama, Kanagawa, Japan

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Yokohama, Kanagawa, Japan

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Yokosuka, Kanagawa, Japan

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Yokosuka, Kanagawa, Japan

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Yokosuka, Kanagawa, Japan

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Kumamoto, Kumamoto, Japan

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Kumamoto, Kumamoto, Japan

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Yamaga, Kumamoto, Japan

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Kyoto, Kyoto, Japan

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Kyoto, Kyoto, Japan

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Maizuru, Kyoto, Japan

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Uji, Kyoto, Japan

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Yosa Gun, Kyoto, Japan

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Ise, Mie-ken, Japan

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Tsu, Mie-ken, Japan

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Sendai, Miyagi, Japan

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Miyazaki, Miyazaki, Japan

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Matsumoto, Nagano, Japan

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Niigata, Niigata, Japan

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Ōita, Oita Prefecture, Japan

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Okayama, Okayama-ken, Japan

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Okayama, Okayama-ken, Japan

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Okayama, Okayama-ken, Japan

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Okayama, Okayama-ken, Japan

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Izumisano, Osaka, Japan

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Kawachi-Nagano, Osaka, Japan

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Osaka, Osaka, Japan

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Osaka, Osaka, Japan

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Osaka, Osaka, Japan

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Suita, Osaka, Japan

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Suita, Osaka, Japan

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Suita, Osaka, Japan

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Takaishi, Osaka, Japan

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Takatsuki, Osaka, Japan

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Saga, Saga-ken, Japan

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Taku, Saga-ken, Japan

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Ageo, Saitama, Japan

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Koshigaya, Saitama, Japan

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Saitama, Saitama, Japan

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Saitama, Saitama, Japan

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Moriyama, Shiga, Japan

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Hamada, Shimane, Japan

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Nikkō, Tochigi, Japan

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Tokushima, Tokushima, Japan

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Chuoku, Tokyo, Japan

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Hachiōji, Tokyo, Japan

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Hachiōji, Tokyo, Japan

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Higashikurume, Tokyo, Japan

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Kodaira, Tokyo, Japan

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Ōta-ku, Tokyo, Japan

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Shibuyaku, Tokyo, Japan

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Shinagawa City, Tokyo, Japan

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Sinagawa Ku, Tokyo, Japan

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Taitoku, Tokyo, Japan

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Toshimaku, Tokyo, Japan

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Gobō, Wakayama, Japan

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Shingū, Wakayama, Japan

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Wakayama, Wakayama, Japan

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Wakayama, Wakayama, Japan

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Kofu, Yamanashi, Japan

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Countries

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Japan

References

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Yokote K, Ako J, Kitagawa K, Osada N, Sheng F, Sonoda M, Teramoto T. Safety and Effectiveness of Low-Density Lipoprotein Cholesterol-Lowering Therapy With Evolocumab for Familial Hypercholesterolemia/Hypercholesterolemia in Japan: A Real-World, Postmarketing, Single-Arm Study. J Am Heart Assoc. 2024 Nov 5;13(21):e035809. doi: 10.1161/JAHA.124.035809. Epub 2024 Oct 29.

Reference Type DERIVED
PMID: 39470058 (View on PubMed)

Other Identifiers

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20140409

Identifier Type: -

Identifier Source: org_study_id

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