Efficacy & Long-term Safety Comparison Study of NK-104-CR & Livalo® IR With Primary Hyperlipidemia or Mixed Dyslipidemia

NCT ID: NCT02799758

Last Updated: 2021-05-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

PHASE3

Study Classification

INTERVENTIONAL

Study Start Date

2016-02-29

Study Completion Date

2017-11-30

Brief Summary

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The purpose of this study is to demonstrate the superior efficacy of NK-104-CR 8 mg daily compared to Livalo® IR 4 mg daily on fasting serum low-density lipoprotein cholesterol (LDL-C) reduction and to evaluate the comparative safety of NK-104-CR 8 mg daily to Livalo® IR 4 mg daily after long-term treatment

Detailed Description

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Conditions

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Hyperlipidemia Dyslipidemia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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NK-104-CR

NK-104-CR 8 mg tablet and Placebo (for Livalo® IR 4 mg tablet) orally once daily for 52 weeks.

Group Type EXPERIMENTAL

NK-104-CR

Intervention Type DRUG

NK-104-CR 8 mg for 52 weeks

Placebo (for Livalo® IR)

Intervention Type DRUG

Livalo® IR 4 mg placebo for 52 weeks

Livalo® IR

Livalo® IR 4 mg tablet and Placebo (for NK-104-CR 8 mg tablet) orally once daily for 52 weeks.

Group Type ACTIVE_COMPARATOR

Livalo® IR

Intervention Type DRUG

Livalo® IR 4 mg daily for 52 weeks

Placebo (for NK-104-CR)

Intervention Type DRUG

NK-104-CR 8 mg placebo for 52 weeks

Interventions

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NK-104-CR

NK-104-CR 8 mg for 52 weeks

Intervention Type DRUG

Livalo® IR

Livalo® IR 4 mg daily for 52 weeks

Intervention Type DRUG

Placebo (for NK-104-CR)

NK-104-CR 8 mg placebo for 52 weeks

Intervention Type DRUG

Placebo (for Livalo® IR)

Livalo® IR 4 mg placebo for 52 weeks

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Male and female patients with primary hyperlipidemia or mixed dyslipidemia
* Patients for whom lipid-lowering therapy is indicated according to NCEP ATPIII
* Patients who are naïve to statin or who are able to safely discontinue the use of all lipid-lowering agents for 4 weeks before randomization and throughout study participation

Exclusion Criteria

* Homozygous familial hypercholesterolemia;
* Any conditions which may cause secondary dyslipidemia.
* Newly diagnosed or poorly controlled diabetes mellitus as defined by HbA1c \>9%
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Kowa Research Institute, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Foley, Alabama, United States

Site Status

Huntsville, Alabama, United States

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Montgomery, Alabama, United States

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Muscle Shoals, Alabama, United States

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Little Rock, Arkansas, United States

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Greenbrae, California, United States

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Huntington Park, California, United States

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Lomita, California, United States

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Long Beach, California, United States

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Los Angeles, California, United States

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Santa Ana, California, United States

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Spring Valley, California, United States

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Tustin, California, United States

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Walnut Creek, California, United States

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Milford, Connecticut, United States

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Atlantis, Florida, United States

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Cooper City, Florida, United States

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Coral Springs, Florida, United States

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Fleming Island, Florida, United States

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Jacksonville, Florida, United States

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Miami, Florida, United States

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Oviedo, Florida, United States

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Dawsonville, Georgia, United States

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Macon, Georgia, United States

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Suwanee, Georgia, United States

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Addison, Illinois, United States

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Chicago, Illinois, United States

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Gurnee, Illinois, United States

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Morton, Illinois, United States

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Evansville, Indiana, United States

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Topeka, Kansas, United States

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Louisville, Kentucky, United States

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Owensboro, Kentucky, United States

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Oxon Hill, Maryland, United States

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Biloxi, Mississippi, United States

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Olive Branch, Mississippi, United States

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Jefferson City, Missouri, United States

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St Louis, Missouri, United States

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Omaha, Nebraska, United States

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Manlius, New York, United States

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High Point, North Carolina, United States

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Salisbury, North Carolina, United States

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Wilmington, North Carolina, United States

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Winston-Salem, North Carolina, United States

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Fargo, North Dakota, United States

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Cincinnati, Ohio, United States

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Columbus, Ohio, United States

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Franklin, Ohio, United States

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Oklahoma City, Oklahoma, United States

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Medford, Oregon, United States

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Beaver, Pennsylvania, United States

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Harleysville, Pennsylvania, United States

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Jersey Shore, Pennsylvania, United States

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Philadelphia, Pennsylvania, United States

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Pittsburgh, Pennsylvania, United States

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Moncks Corner, South Carolina, United States

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Simpsonville, South Carolina, United States

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Summerville, South Carolina, United States

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Austin, Texas, United States

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Houston, Texas, United States

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Katy, Texas, United States

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Plano, Texas, United States

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Round Rock, Texas, United States

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San Antonio, Texas, United States

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Salt Lake City, Utah, United States

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Richmond, Virginia, United States

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Suffolk, Virginia, United States

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Seattle, Washington, United States

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Kenosha, Wisconsin, United States

Site Status

Countries

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United States

Other Identifiers

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NK-104-CR-3.02US

Identifier Type: -

Identifier Source: org_study_id

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