Reasons for Prehospital Delay in Patients With Acute Ischemic Stroke

NCT ID: NCT02798770

Last Updated: 2018-10-10

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 337 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2015-08-31
• Study Completion Date: 2017-11-30

Brief Summary

Ischemic stroke is the leading cause of acquired disability among adults, and one of the main causes of death. In Switzerland, the approved time window for stroke treatment with intravenous thrombolysis after symptom onset is 4.5 h. Even within the 4.5 h time-window, however, the benefit of treatment strongly decreases as time passes.

Moreover, only around 10% patients receive thrombolytic treatment, since patients with stroke arrive too late to the hospital (prehospital delay). Despite efforts to educate the community on the symptom of stroke, prehospital delay did not decrease over time, and the reasons remain incompletely understood. Prehospital delay reduces the proportion of patients with ischemic stroke treated with thrombolysis, and reduces the odds of favorable outcome among the minority treated with thrombolysis.

This prospective cohort study aims at understanding the causes of prehospital delay among patients with acute ischemic stroke. Trained study-nurses will interview, at the bedside, patients and proxies along a standardized questionnaire on prehospital delay. Avoiding modificables causes of prehospital delay may increase the thrombolysis rate and improve outcomes after stroke.

Conditions

Acute Ischemic Stroke

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Stroke Center Basel

No Intervention Foreseen

Intervention Type: OTHER

Interventions

No Intervention Foreseen

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Patients with an acute ischemic stroke hospitalized in the Stroke Center of the University Hospital Basel.

Exclusion Criteria

• Patient not able to answer the in-person, bedside questionnaire asked by a trained study Nurse.
• Patient not willing to participate to the study

• Minimum Eligible Age: 17 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University Hospital, Basel, Switzerland

OTHER

Sponsor Role: lead

Responsible Party

Gian Marco De Marchis

MD MSc Priv. Doz.

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Stroke Center University Hospital Basel

Basel, , Switzerland

Countries

Switzerland

References

Fladt J, Meier N, Thilemann S, Polymeris A, Traenka C, Seiffge DJ, Sutter R, Peters N, Gensicke H, Fluckiger B, de Hoogh K, Kunzli N, Bringolf-Isler B, Bonati LH, Engelter ST, Lyrer PA, De Marchis GM. Reasons for Prehospital Delay in Acute Ischemic Stroke. J Am Heart Assoc. 2019 Oct 15;8(20):e013101. doi: 10.1161/JAHA.119.013101. Epub 2019 Oct 2.

Reference Type: DERIVED

PMID: 31576773 (View on PubMed)

Other Identifiers

UBE-15/64

Identifier Type: -

Identifier Source: org_study_id