Trial Outcomes & Findings for Treating Non-epileptic Seizures Using Magnetic Brain Stimulation (NCT NCT02796924)

Last Updated: 2020-09-30

Results Overview

Number of weekly seizure-events recorded using seizure logs.

Recruitment status

COMPLETED

Study phase

Target enrollment

10 participants

Primary outcome timeframe

One week and three months post-rTMS treatment

Results posted on

2020-09-30

Participant milestones
Measure	Patients 30 sessions of high-frequency (20Hz) repetitive stimulation applied over the right temporal-parietal junction in patients with psychogenic non-epileptic seizures using a MagStim Rapid2 Transcranial Magnetic Simulation machine. MagStim Rapid2 Transcranial Magnetic Simulation: A non-invasive method of brain stimulation
Overall Study STARTED	10
Overall Study COMPLETED	10
Overall Study NOT COMPLETED	0

Withdrawal data not reported

Treating Non-epileptic Seizures Using Magnetic Brain Stimulation

Baseline characteristics by cohort
Measure	Patients n=10 Participants 30 sessions of high-frequency (20Hz) repetitive stimulation applied over the right temporal-parietal junction in patients with psychogenic non-epileptic seizures using a MagStim Rapid2 Transcranial Magnetic Simulation machine. MagStim Rapid2 Transcranial Magnetic Simulation: A non-invasive method of brain stimulation
Age, Continuous	44.9 years STANDARD_DEVIATION 8.0 • n=5 Participants
Sex/Gender, Customized Gender · Female	7 Participants n=5 Participants
Sex/Gender, Customized Gender · Male	3 Participants n=5 Participants
Sex: Female, Male Female	8 Participants n=5 Participants
Sex: Female, Male Male	2 Participants n=5 Participants
Race (NIH/OMB) American Indian or Alaska Native	0 Participants n=5 Participants
Race (NIH/OMB) Asian	0 Participants n=5 Participants
Race (NIH/OMB) Native Hawaiian or Other Pacific Islander	0 Participants n=5 Participants
Race (NIH/OMB) Black or African American	0 Participants n=5 Participants
Race (NIH/OMB) White	2 Participants n=5 Participants
Race (NIH/OMB) More than one race	1 Participants n=5 Participants
Race (NIH/OMB) Unknown or Not Reported	7 Participants n=5 Participants
Region of Enrollment Canada	10 Participants n=5 Participants
Number of weekly seizure-events	8.1 events STANDARD_DEVIATION 6.0 • n=5 Participants

Timeframe: One week and three months post-rTMS treatment

Number of weekly seizure-events recorded using seizure logs.

Outcome measures
Measure	Patients n=10 Participants 30 sessions of high-frequency (20Hz) repetitive stimulation applied over the right temporal-parietal junction in patients with psychogenic non-epileptic seizures using a MagStim Rapid2 Transcranial Magnetic Simulation machine. MagStim Rapid2 Transcranial Magnetic Simulation: A non-invasive method of brain stimulation
Number of Weekly Psychogenic Non-epileptic Seizure-events One week post-rTMS	6.9 events Standard Deviation 15.5
Number of Weekly Psychogenic Non-epileptic Seizure-events Three months post-rTMS	5.3 events Standard Deviation 9.6

Serious events: 0 serious events

Other events: 9 other events

Deaths: 0 deaths

Adverse event data not reported

Other adverse events
Measure	Patients n=10 participants at risk 30 sessions of high-frequency (20Hz) repetitive stimulation applied over the right temporal-parietal junction in patients with psychogenic non-epileptic seizures using a MagStim Rapid2 Transcranial Magnetic Simulation machine. MagStim Rapid2 Transcranial Magnetic Simulation: A non-invasive method of brain stimulation
Nervous system disorders Headache	60.0% 6/10 • Number of events 6 • 4 months
Nervous system disorders Fatigue	40.0% 4/10 • Number of events 4 • 4 months
Nervous system disorders Vivid dreams	40.0% 4/10 • Number of events 4 • 4 months
Nervous system disorders Pain	10.0% 1/10 • Number of events 1 • 4 months
Nervous system disorders Nausea	10.0% 1/10 • Number of events 1 • 4 months
Nervous system disorders Migraine	10.0% 1/10 • Number of events 1 • 4 months

University of Manitoba

Phone: 2042372303