Feasibility and Reproducibility of T1 Rho MRI in the Evaluation of Hip Cartilage

NCT ID: NCT02792010

Last Updated: 2025-09-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

31 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-05-31

Study Completion Date

2016-01-31

Brief Summary

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Hip osteoarthritis is a frequent and invalidating disease. Early detection of cartilage modifications could provide better patient treatment. The T1rho MRI sequence allows the quantification of the cartilage signal that is correlated to modifications of the cartilage matrix, notably of the proteoglycans. The primary objective is to evaluate normal values of hip cartilage in vivo using T1rho MRI in healthy subjects and the reproducibility of the measurements. T1rho and T2 mapping sequences were acquired twice during the same session with 30 minutes interval to see if values were modified after a 30 minutes delay in a supine position. The secondary objective was to assess the correlation between T1rho and T2 values.

Detailed Description

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Conditions

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Healthy Volunteers

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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T1rho MRI

Patients included had hip cartilage MRI with acquisition of T1rho MRI sequence.

Group Type EXPERIMENTAL

Hip cartilage MRI

Intervention Type DEVICE

Hip cartilage MRI

Interventions

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Hip cartilage MRI

Hip cartilage MRI

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* BMI \<30
* Accepting to participate in the study and signed the written informed consent
* Covered by a health insurance system

Exclusion Criteria

* Pregnant woman or risk of pregnancy
* MRI contraindication
* Protected adults
* Language barrier
* Previous or current hip pain
Minimum Eligible Age

18 Years

Maximum Eligible Age

49 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Hospices Civils de Lyon

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jean-Baptiste PIALAT, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Hospices Civils de Lyon

Locations

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Hospices Civils de Lyon - Hôpital Edouard Herriot Pavillon B Radiologie

Lyon, , France

Site Status

Countries

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France

References

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Nemeth A, Di Marco L, Boutitie F, Sdika M, Grenier D, Rabilloud M, Beuf O, Pialat JB. Reproducibility of in vivo magnetic resonance imaging T1 rho and T2 relaxation time measurements of hip cartilage at 3.0T in healthy volunteers. J Magn Reson Imaging. 2018 Apr;47(4):1022-1033. doi: 10.1002/jmri.25799. Epub 2017 Jun 26.

Reference Type BACKGROUND
PMID: 28650110 (View on PubMed)

Other Identifiers

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69HCL14_0235

Identifier Type: -

Identifier Source: org_study_id

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