Brief Intervention for OCD Fears

NCT ID: NCT02790710

Last Updated: 2023-04-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

PHASE4

Study Classification

INTERVENTIONAL

Study Start Date

2016-06-30

Study Completion Date

2023-04-30

Brief Summary

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The study will test the efficacy of propranolol or placebo, administered after reactivation of a previously acquired obsessive-compulsive disorder (OCD) fear, in reducing fear and avoidance in OCD.

Detailed Description

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Twenty subjects with OCD will be enrolled in the study. Participants will complete baseline assessments of fear and avoidance. Participants will be randomly assigned to a single dose of propranolol 40mg or placebo, administered immediately after a fear reactivation procedure. Primary outcome assessment will be OCD symptoms and avoidance behavior in a behavioral avoidance task 2 weeks after the intervention

Conditions

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Obsessive-compulsive Disorder

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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Propanolol

Propranolol 40 mg capsule, given once after fear reactivation procedure

Group Type EXPERIMENTAL

Propanolol

Intervention Type DRUG

Active treatment

Placebo capsule

Placebo capsule, given once after fear reactivation procedure

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Interventions

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Propanolol

Active treatment

Intervention Type DRUG

Placebo

Intervention Type DRUG

Other Intervention Names

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Inderal sugar pill

Eligibility Criteria

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Inclusion Criteria

* Principal Diagnosis of Obsessive-Compulsive Disorder

Exclusion Criteria

* History of other serious psychiatric disorder
* Current Major Depressive Disorder
* Women who are pregnant or nursing
* Current use of psychiatric medication
* Persons planning to start another treatment during the study period
* Any significant medical condition that might increase the risk or participation or use of medications that might negatively interact with propranolol
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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New York State Psychiatric Institute

OTHER

Sponsor Role lead

Responsible Party

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Franklin Schneier

Research Scientist

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Blair Simpson, MD

Role: STUDY_DIRECTOR

New York State Psychiatric Institute

Locations

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New York State Psychiatric Institute

New York, New York, United States

Site Status

Countries

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United States

Other Identifiers

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7293 (OCD)

Identifier Type: -

Identifier Source: org_study_id

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