Shared Decision Making With Anal Cancer Patients on Radiation Dose

NCT ID: NCT02785263

Last Updated: 2025-07-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

27 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-06-30

Study Completion Date

2025-06-30

Brief Summary

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The purpose of this study is to maximize patient involvement in the treatment of anal cancer. Specifically, the investigators will investigate whether patients wish to take part in the decision making on radiation dose and whether they want a high or low radiation dose.

Detailed Description

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The study will also provide new knowledge on the effect and side effects of irradiation of anal cancer, and detailed data from the dose planning will be instrumental in optimizing future decision aids.

Conditions

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Anal Cancer

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Standard radiotherapy

Daily on weekdays: 2.15 gray for tumor and verified lymph node metastases and 1.8 gray for the elective volume. A total of 28 treatments

Group Type OTHER

2.15 gray and 1.8 gray. Max. 6 weeks.

Intervention Type RADIATION

High dose radiotherapy

Daily on weekdays: 2.15 gray for tumor and verified lymph node metastases and 1.8 gray for the elective volume. A total of 28 treatments

Group Type OTHER

2.15 gray and 1.8 gray. Max. 6 weeks.

Intervention Type RADIATION

Low dose radiotherapy

Daily on weekdays: 2.15 gray for tumor and verified lymph node metastases and 1.8 gray for the elective volume. A total of 25 treatments

Group Type OTHER

2.15 gray and 1.8 gray. Max. 5 weeks.

Intervention Type RADIATION

Interventions

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2.15 gray and 1.8 gray. Max. 6 weeks.

Intervention Type RADIATION

2.15 gray and 1.8 gray. Max. 5 weeks.

Intervention Type RADIATION

Eligibility Criteria

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Inclusion Criteria

* Squamous cell carcinoma of the anal duct or perianal (non-hairy skin, max 5 cm from the anal verge)
* T2-T4 N0-3
* Age ≥ 18 years
* Performance status 0-2
* Sufficient organ and bone marrow function defined as:

* Neutrophils ≥ 1.5 x 10\^9/L
* Thrombocytes ≥ 100 x 10\^9/L
* Curative intent radiation treatment deemed possible
* Patients chooses 1 of 3 options:

* I do not wish to decide on details of my treatment, but I would like to receive the standard treatment
* I want to receive the high radiation dose
* I want to receive the low radiation dose
* Written and orally informed consent

Exclusion Criteria

* Non-resectable metastases
* Tumor \> 10 cm or the total tumor volume (incl. lymph node metastases) is too large to be included in an appropriate radiation field (after possible neoadjuvant chemotherapy)
* Pregnant or breastfeeding women
* Fertile women not willing to use effective contraception
* Serious co-morbidity that would hinder interfere with radiation treatment or hinder patient compliance (e.g. incapacity to understand or complete questionnaires)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Vejle Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Lars H Jensen, MD,PhD

Role: STUDY_CHAIR

Vejle Hospital

Locations

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Vejle Hospital

Vejle, , Denmark

Site Status

Countries

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Denmark

Other Identifiers

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PC-Anal-01

Identifier Type: -

Identifier Source: org_study_id

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